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抗Mouse (Murine) RIP2 抗体:
抗Human RIP2 抗体:
抗Rat (Rattus) RIP2 抗体:
RIP2 (显示 ARHGDIG 抗体)-knockout attenuates cardiac injury and dysfunction in hypertrophic heart. RIP2 (显示 ARHGDIG 抗体)-deficience alleviates inflammation in heart of hypertrophic mice. RIP2 (显示 ARHGDIG 抗体)-deletion inhibits fibrosis in the heart of hypertrophic mice.
this study reveals that LRRK2 (显示 LRRK2 抗体) is a new positive regulator of Rip2 (显示 ARHGDIG 抗体) and promotes inflammatory cytokine induction through the Nod1 (显示 NOD1 抗体)/2-Rip2 (显示 ARHGDIG 抗体) pathway.
that Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia
Bacterial polysaccharide-responsive miR (显示 MLXIP 抗体)-150 and miR (显示 MLXIP 抗体)-143 RIPK2 (显示 RIPK2 抗体) and TAK1 (显示 NR2C2 抗体) to suppress NOD2 (显示 NOD2 抗体)-induced immunomodulators.
NOD2 (显示 NOD2 抗体) downregulates colonic inflammation by IRF4 (显示 IRF4 抗体)-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6 (显示 TRAF6 抗体).
RIPK2 (显示 RIPK2 抗体) has a role in NOD signalling and in inflammatory cytokine production
Rip2 (显示 ARHGDIG 抗体)-deficient tumors showed enhanced epithelial-to-mesenchymal transition, with elevated expression of zeb1 (显示 ZEB1 抗体), zeb2 (显示 ZEB2 抗体), twist, and snail (显示 SNAI1 抗体) in the tumor microenvironment.
data show that Nod1 (显示 NOD1 抗体), Nod2 (显示 NOD2 抗体) and Rip2 (显示 ARHGDIG 抗体) are not required for local chemokine (显示 CCL1 抗体) production and neutrophil recruitment during CLP (显示 HAPLN1 抗体)-induced sepsis, and they reinforce the importance of MyD88 (显示 MYD88 抗体)-dependent signaling for initiation of a protective host response.
Suggest that the Nod2 (显示 NOD2 抗体)-Rip2 (显示 ARHGDIG 抗体) axis may contribute to the innate immune response of neutrophils against bacterial infection.
Nod/Ripk2 (显示 RIPK2 抗体) signaling in dendritic cells activates IL-17A (显示 IL17A 抗体)-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2 (显示 RAG2 抗体)-/- (TRUC) mice.
RIP2 (显示 ARHGEF28 抗体) kinase auto-phosphorylation is intimately coupled to dimerization.
study provides structural and dynamic insights into the NOD1 (显示 NOD1 抗体)-RIP2 (显示 ARHGEF28 抗体) oligomer formation, which will be crucial in understanding the molecular basis of NOD1 (显示 NOD1 抗体)-mediated CARD-CARD interaction in higher and lower eukaryotes
a new function of PAX5 (显示 PAX5 抗体) in regulating RIP1 (显示 UQCRFS1 抗体) and RIP2 (显示 ARHGEF28 抗体) activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported.
this study reveals that LRRK2 (显示 LRRK2 抗体) is a new positive regulator of Rip2 (显示 ARHGEF28 抗体) and promotes inflammatory cytokine induction through the Nod1 (显示 NOD1 抗体)/2-Rip2 (显示 ARHGEF28 抗体) pathway.
Together, the data demonstrate that the NOD2 (显示 NOD2 抗体)-RIP2 (显示 ARHGEF28 抗体) pathway is activated in murine and human visceral leishmaniasis and plays a role in shaping adaptive immunity toward a Th1 (显示 TH1L 抗体) profile.
RIP2 (显示 ARHGEF28 抗体) and RhoGDI (显示 ARHGDIA 抗体) bind to p75(NTR (显示 NGFR 抗体)) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 (显示 ARHGEF28 抗体) recruitment displaces RhoGDI (显示 ARHGDIA 抗体) upon ligand binding.
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2 (显示 RIPK2 抗体)) and calcium/calmodulin-dependent protein kinase (显示 CAMK2 抗体) 1alpha (CAMK1alpha).
RIPK1 (显示 RIPK1 抗体) and RIPK2 (显示 RIPK2 抗体) are targets of HIV-1 Protease activity during infection, and their inactivation may contribute to modulation of cell death and host defense pathways by HIV-1
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
receptor-interacting serine/threonine-protein kinase 2
, tyrosine-protein kinase RIPK2
, CARD-carrying kinase
, CARD-containing IL-1 beta ICE-kinase
, CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
, growth-inhibiting gene 30
, receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
, receptor-interacting protein 2