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|抗原||IL2-Inducible T-Cell Kinase (ITK) 抗体|
|抗原表位||AA 1-26 其他选择|
|适用||人, 小鼠 其他选择|
|标记||This ITK antibody is un-conjugated 其他选择|
Immunoprecipitation (IP), Western Blotting (WB)
|Supplier||Log in to see|
ITK抗体详情ITK目标详情 使用细节 贮存及处理 References for anti-ITK antibody (ABIN967287) 图像
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|纯化方法||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|免疫原||Fusion protein with aa.1-26 of human/mouse Itk|
ITK目标详情ITK抗体详情 使用细节 贮存及处理 References for anti-ITK antibody (ABIN967287) 图像 回页首
|别名||ITK (ITK Antibody 摘要)|
|背景||Itk (IL-2 inducible tyrosine kinase) is a member of the TEC family of intracellular tyrosine kinases. Members of this family are characterized by their role in hematopoietic cell signaling. Itk is expressed primarily in T cells and has been shown to play a role in T-cell antigen receptor (TCR) mediated proliferation, interleukin-2 production, and T cell differentiation. Itk, following stimulation of the TCR becomes phosphorylated on tyrosine 511 by the Src kinase Lck resulting in increased in vitro Itk kinase activity. If phenylalanine is substituted for tyrosine at position 511, the in vivo kinase activity of Itk is drastically diminished, indicating that this site plays a key role in regulating Itk function. Itk migrates at ~72 kDa on SDS/PAGE. (SWISSPROT: Q08881)|
|途径||TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
使用细节ITK抗体详情 ITK目标详情 贮存及处理 References for anti-ITK antibody (ABIN967287) 图像 回页首
Related Products: ABIN968537
贮存及处理ITK抗体详情 ITK目标详情 使用细节 References for anti-ITK antibody (ABIN967287) 图像 回页首
|缓冲液||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store undiluted at 4°C.|
References for anti-ITK antibody (ABIN967287)ITK抗体详情 ITK目标详情 使用细节 贮存及处理 图像 回页首
Liu, Bunnell, Gurniak, Berg: "T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." in: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, 1998
Heyeck, Wilcox, Bunnell, Berg: "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25401-8, 1997
Siliciano, Morrow, Desiderio: "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11194-8, 1993
图像ITK抗体详情 ITK目标详情 使用细节 贮存及处理 References for anti-ITK antibody (ABIN967287) 回页首