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Human Cytoplasmic Protein NCK1 Protein expressed in Mouse - ABIN1774727
Borroto, Arellano, Dopfer, Prouza, Suchànek, Fuentes, Orfao, Schamel, Alarcón: Nck recruitment to the TCR required for ZAP70 activation during thymic development. in Journal of immunology (Baltimore, Md. : 1950) 2013
There was no difference in the Nck1 mRNA expression between the SLE patients and the healthy subjects.
this study highlights an important role for Nck1 in fine-tuning IRE1alpha (显示 ERN1 蛋白) expression and signaling that regulate PTP1B (显示 PTPN1 蛋白) expression and subsequent activation of the PI3K (显示 PIK3CA 蛋白)-Akt (显示 AKT1 蛋白) pathway in HepG2 cells.
These findings suggest a novel STAT3 (显示 STAT3 蛋白) to NCK1 to PAK1 (显示 PAK1 蛋白)/ERK (显示 EPHB2 蛋白) signaling mechanism that is potentially critical for colorectal cancer metastasis and angiogenesis.
Authors provide evidence that Nck is an upstream regulator of RhoA (显示 RHOA 蛋白)-dependent, MMP14 (显示 MMP14 蛋白)-mediated breast carcinoma cell invasion.
Nck1 and Nck2 (显示 NCK2 蛋白) Interact with WTIP (显示 WTIP 蛋白). Nck1/2 integrates nephrin (显示 NPHS1 蛋白) with the Hippo kinase cascade through association with the adaptor protein WTIP (显示 WTIP 蛋白).
Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.
the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon (显示 CD3E 蛋白), as it is based on two cooperating interactions.
Nck was the most potent activator of N-WASP-driven actin assembly.
TSAD (显示 SH2D2A 蛋白) binds to and co-localizes with Nck. Expression of TSAD (显示 SH2D2A 蛋白) increases both Nck-Lck (显示 LCK 蛋白) and Nck-SLP-76 (显示 LCP2 蛋白) interaction in T cells.
these data identify Nck as an important mediator of oxidative stress-induced (显示 SQSTM1 蛋白) inflammation and a potential therapeutic target for ischemia/reperfusion injury.
Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts.
These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord
Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4 (显示 CD4 蛋白)(+) T cells.
Nck may function as an effector of T-cell receptor conformational changes during T cell development.
Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Nck1 negatively regulates PERK (显示 EIF2AK3 蛋白) by interacting with PERK (显示 EIF2AK3 蛋白) and protecting PERK (显示 EIF2AK3 蛋白) from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin (显示 INS 蛋白) biogenesis.
that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon (显示 CD3E 蛋白) interaction may represent a target for pharmacological modulation of the immune response.
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
NCK tyrosine kinase
, SH2/SH3 adaptor protein NCK-alpha
, cytoplasmic protein NCK1
, melanoma NCK protein
, non-catalytic region of tyrosine kinase
, non-catalytic region of tyrosine kinase adaptor protein 1
, NCK adaptor protein 1
, cytoplasmic protein NCK1-like
, NCK adaptor protein 1 L homeolog
, SH2/SH3 adaptor protein