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Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
There was no difference in the Nck1 mRNA expression between the SLE patients and the healthy subjects.
this study highlights an important role for Nck1 in fine-tuning IRE1alpha expression and signaling that regulate PTP1B expression and subsequent activation of the PI3K-Akt pathway in HepG2 cells.
These findings suggest a novel STAT3 to NCK1 to PAK1/ERK signaling mechanism that is potentially critical for colorectal cancer metastasis and angiogenesis.
Authors provide evidence that Nck is an upstream regulator of RhoA-dependent, MMP14-mediated breast carcinoma cell invasion.
Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP.
Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.
the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon, as it is based on two cooperating interactions.
Nck was the most potent activator of N-WASP-driven actin assembly.
TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells.
these data identify Nck as an important mediator of oxidative stress-induced inflammation and a potential therapeutic target for ischemia/reperfusion injury.
Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression
Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP).
biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck and N-WASP, is reported.
SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.
These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex.
Nck ubiquitylation might serve as a mechanism controlling Nck-mediated effector functions during cellular activation
the present study characterized a novel Nck-1-ELMO1 interaction and defined a new role for Nck-1 in regulating Rac1 activity.
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation
Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts.
These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord
Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4(+) T cells.
Nck may function as an effector of T-cell receptor conformational changes during T cell development.
Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Nck1 negatively regulates PERK by interacting with PERK and protecting PERK from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin biogenesis.
that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response.
Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly.
Nck1 gene deficiency accelerates mechanical unloading-induced bone loss, suggesting Nck1 to be a crucial molecule in mechanical stress mediated regulation in bone metabolism.
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
The study identifies Nck as a key coordinator of cytoskeletal changes that enable cell polarization and directional migration, which are crucial processes in development and disease.
Nck is recruited to the TCR in an inducible manner in CD4+/CD8+ thymocytes. This recruitment is required for the activation of early TCR-dependent events.
These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly.
Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis.
our findings implicate Nck1 in regulating the unfolded protein response, which secondary to obesity impairs glucose homeostasis and insulin actions
Fine tuning of the threshold of T cell selection by the Nck adapters.
Findings unveil a crucial role for the Nck adaptors in shaping the T-cell repertoire to ensure maximal antigenic coverage and optimal T cell excitability.
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
NCK tyrosine kinase
, SH2/SH3 adaptor protein NCK-alpha
, cytoplasmic protein NCK1
, melanoma NCK protein
, non-catalytic region of tyrosine kinase
, non-catalytic region of tyrosine kinase adaptor protein 1
, NCK adaptor protein 1
, cytoplasmic protein NCK1-like
, NCK adaptor protein 1 L homeolog
, SH2/SH3 adaptor protein