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Human CSK Protein expressed in Wheat germ - ABIN1350517
Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014
Study indicated that MTHFR (显示 MTHFR 蛋白) rs1801133, FGF5 (显示 FGF5 蛋白) rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children.
These results identified a novel role for Csk as a host tyrosine kinase (显示 TXK 蛋白) involved in dengue virus replication.
Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling
Data suggest that myristoylation of Src kinase is essential to facilitate Src (显示 SRC 蛋白)-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase myristoylation, which is required for Src kinase association at cellular membrane, blocks dietary fat-accelerated tumorigenesis.
Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children.
H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation.
Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma.
deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis
Our results do not support association between PTPN22 (显示 PTPN22 蛋白)/CSK and Henoch-Schonlein purpura
Results identify CSK downregulation as a principal driver of SRC (显示 SRC 蛋白) activation and castration resistance.
Our results have uncovered a previously unknown role of c-Src tyrosine kinase in regulating interneuron function in the brain and identified a novel mechanism by which TASK-1 (显示 KCNK3 蛋白) channels are activated in neurons.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (显示 SRC 蛋白), and these findings provide a novel therapeutic target for the treatment of hypertension
Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.
SHIP1 (显示 INPP5D 蛋白) and Csk are part of the PSTPIP2 (显示 PSTPIP2 蛋白)-dependent inhibitory network that prevents the development of autoinflammatory disease.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.
Differentiation of embryonic stem cells is driven by c-Src (显示 SRC 蛋白) is antagonized by c-Yes (显示 YES1 蛋白).
critical role in preventing TCR signaling
It was concluded that c-Src (显示 SRC 蛋白) and NADPH oxidase (显示 NOX1 蛋白) components are necessary for redox-mediated production of TNF-alpha (显示 TNF 蛋白) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.
Dok-4 (显示 DOK4 蛋白) has a role as an anchoring molecule for the tyrosine kinase (显示 TYRO3 蛋白) c-Src (显示 SRC 蛋白), and in turn as a regulator of TNF-alpha (显示 TNF 蛋白)-mediated ROS (显示 ROS1 蛋白) production and NF-kappaB (显示 NFKB1 蛋白) activation
Src (显示 SRC 蛋白) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (显示 NOS2 蛋白) in pulmonary artery endothelium.
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
, protein-tyrosine kinase CYL
, tyrosine-protein kinase CSK
, protein-tyrosine kinase MPK-2
, C-SRC kinase
, protein-tyrosine kinase (CSK)
, protein kinase
, src kinase