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抗Human CD28 抗体:
抗Mouse (Murine) CD28 抗体:
抗Rat (Rattus) CD28 抗体:
Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN1176978
Gelfanov, Lai, Gelfanova, Dong, Su, Liao: Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells. in Journal of immunology (Baltimore, Md. : 1950) 1995
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Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN2689144
Bluestone: New perspectives of CD28-B7-mediated T cell costimulation. in Immunity 1995
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for FACS - ABIN2689149
Wells, Gudmundsdottir, Turka et al.: Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative ... in The Journal of clinical investigation 1998
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Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN370901
Gross, Callas, Allison: Identification and distribution of the costimulatory receptor CD28 in the mouse. in Journal of immunology (Baltimore, Md. : 1950) 1992
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Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, ICC - ABIN457400
Albert, Yu, Martin, Anasetti: Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. in Blood 2005
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Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749055
Guillonneau, Séveno, Dugast, Li, Renaudin, Haspot, Usal, Veziers, Anegon, Vanhove: Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749056
Kerstan, Armbruster, Leverkus, Hünig: Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN611634
van den Brandt, Wang, Reichardt: Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. in Molecular endocrinology (Baltimore, Md.) 2004
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Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN349710
Galea-Lauri, Darling, Gan, Krivochtchapov, Kuiper, Gäken, Souberbielle, Farzaneh: Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN638435
Nunès, Klasen, Ragueneau, Pavon, Couez, Mawas, Bagnasco, Olive: CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. in International immunology 1993
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CD28 may be a tumor suppressor gene and rs3116496 polymorphism of CD28 gene showed positively correlation with the increased risk of breast cancer.
This study demonstrated that GABRG2 (显示 GABRG2 抗体) expression in gamma2 in the cortical nuclei, and amygdalo-hippocampal/parahippocampal-amygdala transition areas.
percentage of CD4 (显示 CD4 抗体)(+) CD28(null) T-cells was significantly higher in type 1 diabetes patients with and without microvascular complications compared with controls
Differential GABRG2 (显示 GABRG2 抗体) structure disturbances are correlated with disease severity.
Suggest that genetic polymorphisms of CD28 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.
the expression of CD28 was lower in both Sjogren's syndrome and systemic sclerosis patients
A recurrent GABRG2 (显示 GABRG2 抗体) missense variant is associated with early-onset seizures, significant motor and speech delays, intellectual disability, hypotonia, movement disorder, dysmorphic features and vision/ocular issues.
The fraction of CD4 (显示 CD4 抗体)(+)CD28(null) cells proved to be predictive on outcome in congestive heart failure-patients presenting with atrial fibrillation.
In this study we systematically evaluated a series of CAR constructs targeting glypican-3 (GPC3 (显示 GPC3 抗体)), which is selectively expressed on several solid tumors. We compared GPC3 (显示 GPC3 抗体)-specific CARs that encoded CD3zeta (显示 CD247 抗体) (Gz) alone or with costimulatory domains derived from CD28 (G28z), 4-1BB (显示 TNFRSF9 抗体) (GBBz), or CD28 and 4-1BB (显示 TNFRSF9 抗体) (G28BBz).
These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4 (显示 CD4 抗体)(+) T lymphocytes.
CD28 may play a role in LPS (显示 TLR4 抗体) nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 (显示 CD80 抗体) in the kidney. High B7-1 (显示 CD80 抗体) expression was detected in podocytes treated with LPS (显示 TLR4 抗体).
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2 (显示 CA2 抗体)+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR (显示 TFRC 抗体) cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR (显示 TFRC 抗体) cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R (显示 CD200R1 抗体)-CD28-transduced leukemia-specific CD8 (显示 CD8A 抗体) T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 (显示 IL2 抗体) administration to sustain in vivo activity.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck (显示 LCK 抗体) complex of protein kinase (显示 CDK7 抗体) Ctheta; (PKCtheta (显示 PRKCQ 抗体);), which serves as a key effector kinase in the CD28 signaling pathway.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP (显示 TXNIP 抗体) and miR33 expression, and this leads to a transient induction of Cpt1a (显示 CPT1A 抗体) and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF (显示 TNF 抗体)
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 (显示 CTLA4 抗体) functions as the main brake but is also dependent on TCR signals and interactions with CD80 (显示 CD80 抗体)/CD86 (显示 CD86 抗体).
data suggest that mPEG PV1 (显示 PLVAP 抗体)-Fab (显示 FANCB 抗体)' acts mainly on IFN-gamma (显示 IFNG 抗体)-producing CD4 (显示 CD4 抗体)+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog