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|抗原||Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) 抗体|
|抗原表位||AA 595-810 其他选择|
|适用||小鸡, 犬, 人, 小鼠, 大鼠 其他选择|
|标记||This CBL antibody is un-conjugated 其他选择|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
CBL抗体详情CBL目标详情 使用细节 贮存及处理 References for anti-CBL antibody (ABIN967971) 图像
|交叉反应||犬, 大鼠, 小鼠, 小鸡|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|纯化方法||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|免疫原||Human c-Cbl aa. 595-810|
CBL目标详情CBL抗体详情 使用细节 贮存及处理 References for anti-CBL antibody (ABIN967971) 图像 回页首
|别名||c-Cbl (CBL Antibody 摘要)|
|背景||Cbl was identified in the genome of a transforming retrovirus from a mouse pre-B cell lymphoma. The product of mammalian c-cbl, p120[cbl], is a widely expressed cytoplasmic protein with several distinctive domains including a RING finger motif and a large proline-rich domain. Although the normal cellular function of c-Cbl has not yet been determined, it associates with many well known signal transduction proteins. In lymphoid cells, c-Cbl is a substrate of TCR-activated protein tyrosine kinases. In addition, stimulation with EGF, PDGF, FGF, or NGF results in tyrosine-phosphorylation of c-Cbl in lymphoid and other cell types. It forms a signaling complex with Grb2 in T cells and is a SH3 and SH2 binding protein which associates with many other cytoplasmic signaling proteins including Btk, Src, fyn, lck, and the beta isoform of PI-3 kinase. Thus, c-Cbl may be an important adaptor protein in growth factor and T-cell receptor signaling pathways. This antibody is routinely tested by western blot analysis.|
|途径||TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals|
使用细节CBL抗体详情 CBL目标详情 贮存及处理 References for anti-CBL antibody (ABIN967971) 图像 回页首
Related Products: ABIN968537, ABIN967389
贮存及处理CBL抗体详情 CBL目标详情 使用细节 References for anti-CBL antibody (ABIN967971) 图像 回页首
|缓冲液||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store undiluted at -20°C.|
References for anti-CBL antibody (ABIN967971)CBL抗体详情 CBL目标详情 使用细节 贮存及处理 图像 回页首
Jiang, Huang, Marusyk, Sorkin: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, 2003
Burke, Schooler, Wiley: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, 2001
Garcia, Miller: "Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3151-7, 2001
Sanjay, Houghton, Neff, DiDomenico, Bardelay, Antoine, Levy, Gailit, Bowtell, Horne, Baron: "Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility." in: The Journal of cell biology, Vol. 152, Issue 1, pp. 181-95, 2001
Donovan, Wange, Langdon, Samelson: "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor." in: The Journal of biological chemistry, Vol. 269, Issue 37, pp. 22921-4, 1994
图像CBL抗体详情 CBL目标详情 使用细节 贮存及处理 References for anti-CBL antibody (ABIN967971) 回页首