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Genetic interaction experiments demonstrate Syx4 (显示 STX4 蛋白), Syt4, and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
A retrograde signal mediated by Synaptotagmin 4 is transmitted to the postsynaptic cell through anterograde delivery of Synaptotagmin 4 via exosomes.
Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE (显示 NAPA 蛋白)-catalyzed membrane fusion.
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (显示 CA2 蛋白)+) binding in the C(2)A domain
results demonstrate that acute plasticity and synapse-specific growth require Syt 4-dependent retrograde signaling at Drosophila neuromuscular junctions
Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 (显示 SYT1 蛋白) as a Ca(2 (显示 CA2 蛋白)+) sensor for presynaptic vesicle fusion.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3 (显示 BAG3 蛋白), APOA1 (显示 APOA1 蛋白), and VAV3 (显示 VAV3 蛋白), except for VGF (显示 VGF 蛋白) protein, there was a trend between the expression of these four genes and their protein levels.
Synaptotagmin 4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased synaptotagmin 4 binding to vesicles.
BDNF (显示 BDNF 蛋白) secretion mediated by syt (显示 SS18 蛋白)-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons
Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
these data suggest that syt (显示 SS18 蛋白) IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals
propose that Syt (显示 SS18 蛋白) IV is essential for the regulated release of glutamate (显示 GRIN1 蛋白) from astrocytes and is a candidate Ca2 (显示 CA2 蛋白)+ sensor for gliotransmission by these nonneuronal cells
Syt (显示 SS18 蛋白) IV plays a role in rodent mood-related behavior by regulating synaptic function in the neuronal networks that modulate these behaviors.
Syt (显示 SS18 蛋白) IV is a presynaptic negative regulator of short-term plasticity in area CA1 (显示 CA1 蛋白) of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory.
Given the neuroendocrine functions of the posterior pituitary, changes in Syt (显示 SS18 蛋白) IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin (显示 AVP 蛋白)
Thus, regulation of BDNF (显示 BDNF 蛋白) secretion by syt (显示 SS18 蛋白)-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP (显示 SCP2 蛋白).
From the results of this study the author proposed that the differential expression of synaptotagmins determines the characteristic Ca2 (显示 CA2 蛋白)+ sensitivity of vesicle fusion at hair cell synapses.
The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues.
, synaptotagmin 4
, synaptotagmin IV