anti-ETV5 (ETV5) 抗体产品概述

Human Ets Variant 5 (ETV5) interaction partners

1. exploration of the underlying mechanism demonstrated that ICAM3 not only binds to LFA-1 with its extracellular domain and structure protein ERM but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis).

2. High Etv5 expression is associated with glioma.

3. four oncogenic ETS (ERG, ETV1, ETV4, and ETV5), and no other ETS, interact with the Ewing's sarcoma breakpoint protein, EWS.

4. Novel ETV5 SNP rs7647305 is associated with childhood hypertension adjusted by obesity.

5. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.

6. the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells

7. MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level, elevated ERM expression, and enhanced cell migration and invasion. MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level, reduced ERM expression, and weakened cell migration and invasion.

8. Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation

9. ERM proteins contribute toward accelerated CD44 shedding by MT1-MMP through ERM protein-mediated interactions between their cytoplasmic tails.

10. Our results reveal a novel ERM-based spatial mechanism that is coopted by DLBCL cells to sustain tumor cell growth and survival.

11. Increase of ETV5 protein expression is associated with endometrial cancer invasion.

12. developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes

13. Snail regulates the motility and invasiveness of oral cancer cells via RhoA/Cdc42/p-ERM pathway.

14. there is a higher expression of ERM/ETV5 in early stages of endometrioid endometrial carcinomas

15. we found that the downregulation of ETV5 reduced the expression of the oncogenic transcription factor FOXM1.

16. This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer.

17. Review evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action.

18. we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.

19. The homozygous +48845 G>T (TT allele) variant confers a higher risk for male infertility associated with nonobstructive azoospermia and Sertoli cell only syndrome in Australian men.

20. Upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model.

Zebrafish Ets Variant 5 (ETV5) interaction partners

1. etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development

2. Zebrafish etv5a is essential for the inhibition of ventral mesoderm cell proliferation and for the formation of the hemato-vascular lineage.

Mouse (Murine) Ets Variant 5 (ETV5) interaction partners

1. CIC-ETV5 axis is critical for regulation of follicular helper T cell development

2. ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis

3. High Etv5 expression is associated with glioma.

4. This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.

5. Etv5 is expressed alveolar type II cells in adult lung.Etv5 is a critical output of Ras signaling in alveolar type II cells, contributing to both lung homeostasis and tumor initiation.

6. SOX9 regulation of ETV5 contributes to the control of male fertility

7. this study shows that Etv5 plays a crucial role in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcription factors at the Il10 locus

8. findings demonstrate that ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation

9. substrate that mediates RFWD2 function in lung branching

10. bioinformatic analysis, real-time PCR, and luciferase assay validated that AK015322 serves as a decoy of microRNA-19b-3p (miR-19b-3p), antagonizes its function, and attenuates the repression of its endogenous target transcriptional factor Ets-variant 5 (ETV5) which was a pivotal gene for spermatogonial stem cell self-renewal

11. Further investigations identified Pak1-ERM as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK signaling ensures timely epithelial apoptotic death at postimplantation.

12. The data of this study suggested that the obesity-associated transcription factor ETV5 normally acts to diminish circulating glucocorticoids.

13. ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.

14. Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments

15. The transcription factors Etv5 and STAt3 control TH17 cell development and allergic airway inflammation.

16. A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse.

17. Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression.

18. found to be a critical downstream regulator of glial cell line-derived neurotrophic factor-signaling that mediated the expression of several known spermatogonial stem cell self-renewal related genes

19. Results suggest that Etv5 is important for the developmental competence of germ cells and the regulation of responses to steroid hormones in female mice.

20. Data show that miR-21 is regulated by the transcription factor ETV5, known to be critical for SSC self-renewal.