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Ataxin 1 蛋白

(Ataxin 1 (ATXN1))

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010].

recommended

Ataxin 1 Protein (ATXN1) (AA 576-675) (GST tag) (ABIN1346189)

ATXN1 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

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recommended

Ataxin 1 Protein (ATXN1) (AA 1-815) (Strep Tag) (ABIN3089722)

Crystallography grade ATXN1 宿主: 人宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA

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recommended

Ataxin 1 Protein (ATXN1) (AA 1-791) (Strep Tag) (ABIN3119805)

Crystallography grade ATXN1 宿主: 小鼠宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA

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Popular Ataxin 1 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Ataxin 1 Protein (ATXN1) (AA 576-675) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1346189

Quantity 10 μg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (AA 1-815) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3089722

Quantity 1 mg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (AA 1-791) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3119805

Quantity 1 mg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (AA 569-807) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7390679

Quantity 100 μg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (AA 331-587) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7415551

Quantity 100 μg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2715012

Quantity 20 μg

Datasheet Datasheet

Ataxin 1 Protein (ATXN1) (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2715013

Quantity 20 μg

Datasheet Datasheet

Latest Publications for our Ataxin 1 蛋白

Yoon, Abdelmohsen, Kim, Yang, Martindale, Tominaga-Yamanaka, White, Orjalo, Rinn, Kreft, Wilson, Gorospe: "Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination." in: Nature communications, Vol. 4, pp. 2939, (2013) (PubMed).

Aliases for Ataxin 1 蛋白

ataxin 1 (ATXN1) 蛋白
ataxin 1b (atxn1b) 蛋白
ataxin 1 (Atxn1) 蛋白
Ataxin 1 (Atx-1) 蛋白
2900016G23Rik 蛋白
ataxin 1b 蛋白
ATX1 蛋白
Atx1 蛋白
ATXN1 蛋白
atxn1 蛋白
C85907 蛋白
CG4547 蛋白
D6S504E 蛋白
dAtx-1 蛋白
dAtx1 蛋白
Dmel\\CG4547 蛋白
ENSMUSG00000074917 蛋白
Gm10786 蛋白
SCA1 蛋白
Sca1 蛋白
sca1 蛋白

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Aliases for Ataxin 1 蛋白

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