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The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA (显示 DROSHA 蛋白) rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 (显示 ESR1 蛋白) rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR (显示 MLXIP 蛋白)-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase (显示 TUT1 蛋白)) Zcchc11 (TUT4) activity.
Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
miR (显示 MLXIP 蛋白)-26a directly targets Lin28B (显示 LIN28B 蛋白) and Zcchc11-two critical repressors of let-7 maturation.
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 (显示 LIN28A 蛋白) uses two different TUTases to control let-7 expression .
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity
TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer (显示 DICER1 蛋白) processing. Knockdown of TUT4 and Lin28 (显示 LIN28A 蛋白) reduces the level of stem cell markers
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (显示 IL22 蛋白) after LPS (显示 IRF6 蛋白) treatment and suppresses the TRAF6 (显示 TRAF6 蛋白)-dependent activation of NF-kappaB (显示 NFKB1 蛋白).
We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 (显示 IGF1 蛋白) expression and enhancing postnatal growth and survival
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (显示 TIFA 蛋白) after LPS (显示 TLR4 蛋白) treatment and suppresses the TRAF6 (显示 TRAF6 蛋白)-dependent activation of NF-kappaB (显示 NFKB1 蛋白).
Zcchc11 fine tunes IL-6 (显示 IL6 蛋白) production by uridylating miR (显示 MLXIP 蛋白)-26a.
Lin28 (显示 LIN28A 蛋白) recruits the TUTase (显示 TUT1 蛋白) Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
ZCCHC11 is an RNA uridyltransferase (EC 188.8.131.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009
PAP associated domain containing 3
, TUTase 4
, terminal uridylyltransferase 4
, zinc finger CCHC domain-containing protein 11
, zinc finger, CCHC domain containing 11
, Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1)-like
, terminal uridylyltransferase 4-like