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The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity.
Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
miR-26a directly targets Lin28B and Zcchc11-two critical repressors of let-7 maturation.
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 uses two different TUTases to control let-7 expression .
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity
TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer processing. Knockdown of TUT4 and Lin28 reduces the level of stem cell markers
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB.
Zcchc11 fine tunes IL-6 production by uridylating miR-26a.
We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 expression and enhancing postnatal growth and survival
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
ZCCHC11 is an RNA uridyltransferase (EC 220.127.116.11) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009
PAP associated domain containing 3
, TUTase 4
, terminal uridylyltransferase 4
, zinc finger CCHC domain-containing protein 11
, zinc finger, CCHC domain containing 11
, Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1)-like
, terminal uridylyltransferase 4-like