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In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer
no association between the PCM1 (显示 MBD1 蛋白) gene and schizophrenia in a Japanese population
Haematological neoplasms associated with t(8;9)(p22 (显示 DYNC1H1 蛋白);p24); PCM1 (显示 MBD1 蛋白)-JAK2 (显示 JAK2 蛋白) have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
these data suggest a mechanism whereby the recruitment of Plk1 to pericentriolar matrix by PCM1 (显示 MBD1 蛋白) plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry.
Chromosomal translocation [t(8;9)(p22 (显示 DYNC1H1 蛋白);p24)]/PCM1 (显示 MBD1 蛋白)-JAK2 (显示 JAK2 蛋白) fusion protein activates SOCS2 (显示 SOCS2 蛋白) and SOCS3 (显示 SOCS3 蛋白) via STAT5 (显示 STAT5A 蛋白) in a cutaneous T-cell lymphoma cell line.
CEP90 (显示 PIBF1 蛋白) physically interacts with PCM-1 (显示 MBD1 蛋白) at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation (显示 PIFO 蛋白).
PCM1 (显示 MBD1 蛋白) interacts with Hook2 (显示 HOOK2 蛋白) in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation.
NEK7 (显示 NEK7 蛋白) is essential for PCM (显示 PCMT1 蛋白) accumulation in a cell cycle stage-specific manner.
MicroRNA (miR (显示 MLXIP 蛋白))-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
haploinsufficiency at the Pcm1 (显示 MBD1 蛋白) locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
deletion of Htt (显示 HTT 蛋白) in ependymal cells led to PCM1 (显示 MBD1 蛋白) mislocalization, alteration of the cilia layer, and hydrocephalus
results identify a novel role for PCM- 1 (显示 MBD1 蛋白) in cell cycle regulation, and indicate that PCM-1 (显示 MBD1 蛋白) must fulfill an essential function for cells to complete interphase
Pcm1 (显示 MBD1 蛋白) colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 (显示 MBD1 蛋白) reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
pericentriolar material 1
, pericentriolar material 1 protein-like
, Pericentriolar material 1 protein-like
, pericentriolar material 1 protein
, pericentriolar material 1, PCM1
, pericentriolar material gene 1
, pericentriolar material-1