Use your antibodies-online credentials, if available.
抗Human HES5 抗体:
抗Mouse (Murine) HES5 抗体:
抗Rat (Rattus) HES5 抗体:
Over-expression of her12, her15 or her7 disrupts cyclic gene expression and somite border formation, and structure function analysis of Her7 indicates that DNA binding, but not Groucho-recruitment seems to be important in this process.
HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 (显示 STAT3 抗体) signaling.
that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma
HES5 silencing is an early and recurrent change in prostate tumourigenesis
these data identify HES5 as a key mediator of the Wnt-3a (显示 WNT3A 抗体) proneurogenic effect occurring independently of the classical Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling cascade thus further deciphering crosstalk mechanisms of Wnt (显示 WNT2 抗体) and Notch (显示 NOTCH1 抗体) signaling pathways regulating cell fate
the downstream Notch (显示 NOTCH1 抗体) signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta.
Notch3 (显示 NOTCH3 抗体) and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL).
Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis.
In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch (显示 NOTCH1 抗体) pathway activation in those cells.
The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control
For marking and purifying neural stem cells to ascertain whether differences exist, we generated transgenic mice using promoters from Hes (显示 RRBP1 抗体) genes (pHes1 or pHes5) to drive expression of destabilized enhanced green fluorescent protein.
Although Hes5-GFP and Hes1 (显示 HES1 抗体) are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 (显示 HES1 抗体) mutants, suggests that this transgene contains the relevant cis (显示 CISH 抗体)-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina.
Hes5 is expressed in the nascent mesoderm of gastrulating mouse embryos. Hes5 knockdown enhances primitive erythropoiesis in mouse embryonic stem cells. A stage-specific pulse of Hes5 instructs preferential cardiac fate in mouse embryonic stem cells.
Sox2 (显示 SOX2 抗体) activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage.
Hes5 regulates the transition timing between phases for specification of neocortical neurons and between neurogenesis and gliogenesis.
the RBPjkappa-dependent Notch (显示 NOTCH1 抗体) targets HES1 (显示 HES1 抗体) and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy.
This study demonstrated that Hes1 (显示 HES1 抗体) and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.
delivery of siRNA to Hes1 (显示 HES1 抗体) and Hes5 using a transfection reagent or siRNA to Hes1 (显示 HES1 抗体) encapsulated within nanoparticles increased hair cell numbers in non-toxin treated organotypic cultures of cochleae and maculae
The transcription and expression patterns of Notch (显示 NOTCH1 抗体) pathway components (Notch 1 (显示 NOTCH1 抗体)-3, Delta1 and 4, Jagged1 (显示 JAG1 抗体)) and effectors (Hes1 (显示 HES1 抗体), Hes2 (显示 HES2 抗体), Hes5 and Nrarp (显示 NRARP 抗体)) were evaluated in the mouse testis
Hes1 (显示 HES1 抗体) and Hes5 regulate vascular remodeling and arterial fate specification of endothelial cells in the development of the brain; they are critical transducers of Notch (显示 NOTCH1 抗体) signals in brain vascular development.
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
hairy and enhancer of split 5
, transcription factor HES-5
, Transcription factor HES-5
, class B basic helix-loop-helix protein 38