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PRMT5 抗体

(Protein Arginine Methyltransferase 5 (PRMT5))
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
PRMT5 抗体  (AA 40-140) PRMT5 抗体  (AA 40-140) PRMT5 抗体 (AA 40-140) (ABIN3022066)

PRMT5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

PRMT5 抗体  (Internal Region) PRMT5 抗体  (Internal Region) PRMT5 抗体 (Internal Region) (ABIN6266359)

PRMT5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

PRMT5 抗体  (AA 21-70) PRMT5 抗体  (AA 21-70) PRMT5 抗体 (AA 21-70) (ABIN203229)

PRMT5 适用: 人, 小鼠, 大鼠, 犬, 兔, 马, 猴, 豚鼠, Pig, Bat, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

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PRMT5 抗体 by 适用

Find PRMT5 抗体 for a variety of species such as anti-Human PRMT5, anti-Mouse PRMT5, anti-Rat PRMT5. The species listed below are among those available. Click on a link to go to the corresponding products.

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PRMT5 抗体 by 克隆形成能力

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Popular PRMT5 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (8)
Cat. No. ABIN3022066
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (4)
Cat. No. ABIN6266359
Quantity 100 μL
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN203229
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN7269605
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7165071
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7127775
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN2778654
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, IF, IP, ChIP, IC
Validations
  • (3)
Cat. No. ABIN7308234
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN3032362
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN3032360
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN523817
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN7260339
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN948939
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ChIP-seq
Validations
  • (1)
Cat. No. ABIN6972554
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN571028
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PRMT5 抗体

Pak, Lee, Roh: "High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma." in: Pathology international, Vol. 65, Issue 10, pp. 541-8, (2015) (PubMed).

Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." in: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).

Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: "PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing." in: Nature structural & molecular biology, Vol. 16, Issue 3, pp. 304-11, (2009) (PubMed).

Pal, Yun, Datta, Lacomis, Erdjument-Bromage, Kumar, Tempst, Sif: "mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad." in: Molecular and cellular biology, Vol. 23, Issue 21, pp. 7475-87, (2003) (PubMed).

Rho, Choi, Seong, Cho, Kim, Im: "Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11393-401, (2001) (PubMed).

Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: "Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14781-6, (1999) (PubMed).

Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, (1999) (PubMed).

Krapivinsky, Pu, Wickman, Krapivinsky, Clapham: "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10811-4, (1998) (PubMed).

Aliases for PRMT5 抗体

protein arginine methyltransferase 5 (PRMT5) 抗体
protein arginine N-methyltransferase 5 (Prmt5) 抗体
protein arginine methyltransferase 5 (Prmt5) 抗体
protein arginine methyltransferase 5 (prmt5) 抗体
protein arginine methyltransferase 5 L homeolog (prmt5.L) 抗体
putative arginine N-methyltransferase, type II (PRMT5) 抗体
Skb1 family protein (prmt5) 抗体
protein arginine N-methyltransferase 5 (LOC100115766) 抗体
Protein arginine N-methyltransferase 5 (prmt-5) 抗体
DDBDRAFT_0187422 抗体
DDBDRAFT_0235403 抗体
DDB_0187422 抗体
DDB_0235403 抗体
HRMT1L5 抗体
hrmt1l5 抗体
hsl7 抗体
IBP72 抗体
ibp72 抗体
JBP1 抗体
Jbp1 抗体
jbp1 抗体
NV18830 抗体
si:zc14a17.2 抗体
SKB1 抗体
Skb1 抗体
skb1 抗体
SKB1Hs 抗体
skb1hs 抗体
wu:fb95f10 抗体
zgc:110669 抗体
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