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Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ (显示 TAZ 蛋白) upregulation.
is not a Notch ligand (显示 JAG2 蛋白)
DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population
These studies implicate DNER as a susceptibility gene for T2DM in American Indians.
Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER).
The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta (显示 CEBPD 蛋白) expression.
This study showed that the DNER is present in ganglion and amacrine cells on P1, also labeling the horizontal cells by P10 (显示 NUTF2 蛋白). Developing AII (显示 ARG2 蛋白) amacrine cells exhibit accumulating DNER labeling at the dendritic stalk, labeling that becomes progressively conspicuous by P10 (显示 NUTF2 蛋白), as it is in maturity.
the present study demonstrated that DNER was expressed in SGNs and appeared to be involved in the mechanisms underlying neuronal polarity and neuritogenesis, via a Notchdependent signaling pathway.
DNER plays a redundant role with other Notch (显示 NOTCH1 蛋白) ligands in cochlear development
DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex (显示 DTX1 蛋白)-dependent Notch (显示 NOTCH1 蛋白) signaling.
These observations suggest that pleiotrophin (显示 PTN 蛋白)-PTPzeta (显示 PTPRZ1 蛋白) signaling controls subcellular localization of DNER and thereby regulates neuritogenesis.
Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.
delta-notch-like EGF repeat-containing transmembrane
, delta and Notch-like epidermal growth factor-related receptor
, delta/notch-like EGF-related receptor
, brain EGF repeat-containing transmembrane protein
, transmembrane protein Bet