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Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (显示 CD6 蛋白) and linker for activation of T cells (显示 LAT 蛋白) protein (LAT (显示 ORC3 蛋白)) phosphotyrosine (pTyr) peptides.
TSAD binds to and co-localizes with Nck (显示 NCK1 蛋白). Expression of TSAD increases both Nck (显示 NCK1 蛋白)-Lck (显示 LCK 蛋白) and Nck (显示 NCK1 蛋白)-SLP-76 (显示 LCP2 蛋白) interaction in T cells.
The kinase Itk (显示 ITK 蛋白) and the adaptor TSAd change the specificity of the kinase Lck (显示 LCK 蛋白) in T cells by promoting the phosphorylation of Tyr192.
Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues.
in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene
TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements
TSAd associates with laminin binding protein (显示 RPSA 蛋白) and mediates T lymphocyte migration during T cell activation
TSAd appears to contribute to interleukin-2 (显示 IL2 蛋白) synthesis at multiple different levels
upon chemokine (显示 CCL1 蛋白) stimulation, Lad (显示 DLD 蛋白) acts as an adaptor protein that links the G protein beta subunit (显示 GNB3 蛋白) to the tyrosine kinases Lck (显示 LCK 蛋白) and Zap-70 (显示 ZAP70 蛋白), thereby mediating T-cell migration
SH2D2A expression is regulated both at the transcriptional and translational level.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen.
Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer.
Data show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) facilitates binding of VEGFR2 (显示 KDR 蛋白) to the Rous sarcoma (Src (显示 SRC 蛋白)) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates VEGF (显示 VEGFA 蛋白)-induced activation of the c-Src tyrosine kinase (显示 CSK 蛋白).
results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells.
role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity
The major role of T cell-specific adapter protein in peripheral T cell cytoplasm is for activation of LCK (显示 LCK 蛋白) protein tyrosine kinase (显示 YES1 蛋白) at the outset of T cell receptor signal transduction
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants.
SH2 domain protein 2A
, SH2 domain-containing protein 2A
, T cell specific adapter protein TSAd
, T lymphocyte specific adaptor protein
, VEGF receptor-associated protein
, Lck-associated adapter protein
, Rlk/Itk-binding protein
, T cell-specific adapter protein
, p56Lck-associated adapter protein