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Human EPAS1 Protein expressed in Wheat germ - ABIN1352871
Coltella, Percio, Valsecchi, Cuttano, Guarnerio, Ponzoni, Pandolfi, Melillo, Pattini, Bernardi: HIF factors cooperate with PML-RAR? to promote acute promyelocytic leukemia progression and relapse. in EMBO molecular medicine 2014
Results suggest an interplay of the production and action of hydrogen sulfide (显示 SQRDL 蛋白) during hypoxia with subsequent erythropoietin (显示 EPO 蛋白) production regulated by HIF-1alpha (显示 HIF1A 蛋白) and HIF-2alpha.
This suggests that higher aerobic capacities are caused by the presence of at least one minor A-Allele of the EPAS1 gene in the genome of an athlete
we report a rare case of renal-cell carcinoma (显示 MOK 蛋白) and hereditary polycythemia. Genotyping revealed that the patient carried both a germline HIF2A mutation and a somatic VHL (显示 VHL 蛋白) mutation. Both mutations result in overactivation of HIF2A and its downstream target genes
Identification of gain-of-function somatic mutations of EPAS1, which encodes for HIF-2alpha, in pheochromocytomas and paragangliomas in patients who presented with cyanotic congenital heart disease.
HIF-2a regulates non-canonical glutamine (显示 GFPT1 蛋白) metabolism via activation of PI3K (显示 PIK3CA 蛋白)/mTORC2 (显示 CRTC2 蛋白) pathway and GOT1 (显示 GOT1 蛋白) expression in human pancreatic ductal adenocarcinoma.
epigenomic profiling of clear cell renal cell carcinoma (显示 MOK 蛋白) (ccRCC) establishes a compendium of somatically altered cis (显示 CISH 蛋白)-regulatory elements, uncovering new potential targets including ZNF395 (显示 ZNF395 蛋白). Loss of VHL (显示 VHL 蛋白), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 (显示 EP300 蛋白) at preexisting lineage-specific promoter-enhancer complexes
We studied the hypoxic activation of the transcription factors HIF-1alpha (显示 HIF1A 蛋白) and HIF-2alpha in endothelial cells within a spatial linear gradient of oxygen. Quantification of the nuclear to cytosolic ratio of HIF immunofluorescent staining demonstrated that the threshold for HIF-1alpha (显示 HIF1A 蛋白) activation was below 2.5% O2 while HIF-2alpha was activated throughout the entire linear gradient.
miRNA-101 level is decreased in RCC (显示 XRCC1 蛋白) tissues/cells, which could be responsible for DNA-PKcs (显示 PRKDC 蛋白) overexpression and DNA-PKcs (显示 PRKDC 蛋白) mediated oncogenic actions; DNA-PKcs (显示 PRKDC 蛋白) over-expression regulates mTORC2 (显示 CRTC2 蛋白)-AKT (显示 AKT1 蛋白) activation, HIF-2alpha expression and RCC (显示 XRCC1 蛋白) cell proliferation
report shows that somatic gain-of-function HIF2A mutations are present in 20% of gangliocytic paragangliomas (GPGLs) in the present series; the mutations appear to be located in the hot spot of the oxygen-sensing domain of HIF-2alpha, resulting in increased HIF-2alpha stabilization and impaired ubiquitination and degradation
these findings establish a new link between HIF-2alpha and MAPK (显示 MAPK1 蛋白)-signaling that mediates the adaptive regulation of mitochondrial gene expression under low oxygen tension.
Defect in nephron formation in PHD2 (显示 EGLN1 蛋白)/PHD3 (显示 EGLN3 蛋白) double mutants required intact hypoxia-inducible factor-2 signaling and was dependent on the extent of stromal hypoxia-inducible factor activation. Thus, hypoxia-inducible factor prolyl-4-hydroxylation in renal interstitial cells is critical for normal nephron formation.
Absence of Hif2a in retinal neuroprogenitor cells causes a marked reduction of proliferating endothelial cells at the angiogenic front. This results in delayed retinal vascular development, fewer major retinal vessels and reduced density of the peripheral deep retinal vascular plexus.
HIF2alpha is linked to tumor suppression in neuroblastoma (显示 ARHGEF16 蛋白).
The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44 (显示 CD44 蛋白), independently of oxygen.
HIF-1alpha (显示 HIF1A 蛋白)-dependent, HIF-2alpha-independent angiogenesis and constitutive diuresis is caused by Vhl (显示 VHL 蛋白) deletion in renal epithelia
A novel biological pathway has been discovered of soluble biglycan (显示 BGN 蛋白) inducing HIF-2alpha protein stabilization and Epo (显示 EPO 蛋白) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Data show that Tet1 (显示 TET1 蛋白) modulates HIF-2alpha and HIF-1alpha (显示 HIF1A 蛋白) through different mechanisms.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (显示 Neu3 蛋白), the gene encoding neuraminidase 3 (显示 Neu3 蛋白). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
immunostaining for HIF-1alpha (显示 HIF1A 蛋白) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a