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Human SIX1 Protein expressed in Wheat germ - ABIN1320061
Yu, Davicioni, Triche, Merlino: The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. in Cancer research 2006
the continuous and complex expression pattern of Six1 during sensory organ formation is pieced together by separate enhancers
Six1 is required for the expression of numerous genes encoding fast-type sarcomeric proteins, glycolytic enzymes and controlling intracellular calcium homeostasis.
our analyses uncover essential roles of Six1 in hair cell differentiation and formation of the organ of Corti in the mammalian cochlea
SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 (显示 JAG1 蛋白) expression but also by inhibiting endothelin 1 (Edn1 (显示 EDN1 蛋白)) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (显示 EDNRA 蛋白) signaling.
significant co-localization of binding sites for MyoD (显示 MYOD1 蛋白) and Six proteins on over a thousand mouse genomic DNA regions, were found.
we show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa (显示 CEBPA 蛋白), C/EBPb (显示 CEBPB 蛋白) and EBF2 (显示 EBF2 蛋白), suggesting their functional cooperation during adipogenesis.
Studies strongly suggest that Six1 overexpression promotes CRC growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (显示 CCNA1 蛋白). MAPK (显示 MAPK1 蛋白) activation may be a pivotal event in Six1-associated tumor progression.
Downregulation of Six1 effectively inhibited airway inflammation and reversed airway remodeling, which suggest that Six1 represents a promising therapeutic strategy for human allergic asthma.
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
We replicated the association of SNP rs10483727 in the SIX1/SIX6 (显示 SIX6 蛋白) locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma .
SIX1 is a potential target gene of miR (显示 MLXIP 蛋白)-30a and down-regulation of SIX1 by siRNA inhibited proliferation and invasion of prostate cancer cells.
Six1 is overexpressed in human primary pancreatic ductal adenocarcinomas and that its inhibition results in a decreased tumour progression in vitro and in vivo.
in non-small cell lung cancer, SIX1-5 were associated with the greater possibility of the tumorigenesis
SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers
SIX homeobox 1 (SIX1) regulates cellular senescence by a p16INK4A (p16)-dependent mechanism.
PTH2R and its ligand TIP39 regulate intracellular calcium and influence keratinocyte differentiation
Studies strongly suggest that Six1 overexpression promotes CRC (显示 CALR 蛋白) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (显示 CCNA1 蛋白). MAPK (显示 MAPK1 蛋白) activation may be a pivotal event in Six1-associated tumor progression.
Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR (显示 MLXIP 蛋白)-362 overexpression in cervical cancer cells. The newly identified miR (显示 MLXIP 蛋白)-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target.
study replicated the association of POAG with two SNPs at the SIX1-SIX6 (显示 SIX6 蛋白) locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (显示 OPA1 蛋白) in patients aged above 40 years
The HD domain is important for the nuclear localization of porcine Six1 protein.
histone H4 and E2F2 (显示 E2F2 蛋白) bind to the -216/-28 region and play important roles in SIX1 methylation regulation during development.
Six1 and Eya1 (显示 EYA1 蛋白) can both promote and arrest neuronal differentiation by activating the Notch (显示 NOTCH1 蛋白) pathway genes.
these findings establish an interaction between Pa2G4 (显示 PA2G4 蛋白) and Six1, and demonstrate that it has an important role in the development of tissues affected in Branchiootorenal Spectrum disorder.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Eya1 (显示 EYA1 蛋白) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1