Use your antibodies-online credentials, if available.
抗Mouse (Murine) 抗体:
抗Rat (Rattus) 抗体:
Human Polyclonal SIX1 Primary Antibody for ICC, IF - ABIN4353939
Wan, Miao, Quraishi, Kennedy, Creek, Pirisi: Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. in International journal of cancer 2008
Show all 15 Pubmed References
Human Polyclonal SIX1 Primary Antibody for ELISA - ABIN562881
Gordon, Delgado Díaz, White, Carson, Kostek: Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. in The journal of physiological sciences : JPS 2012
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SIX1 Primary Antibody for IHC, WB - ABIN2779599
Lee, Kim, Ryu, Lee, Yang, Jeong, Kim, Lee, Kim, Hajjar, Park: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. in Journal of molecular and cellular cardiology 2012
Show all 2 Pubmed References
SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients
Results showed that SIX1 was overexpressed in osteosarcoma tissues, blood samples and cell lines, whereas PTEN expression was reduced.
Knockdown of SIX1 increased cell ROS levels and autophagy, promoted cell apoptosis, and enhanced TAX sensitivity of HepG2 cells.
SIX1/EYA1 mutations might be partially responsible for conotruncal heart defects.
We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma .
SIX1 is a potential target gene of miR-30a and down-regulation of SIX1 by siRNA inhibited proliferation and invasion of prostate cancer cells.
Six1 is overexpressed in human primary pancreatic ductal adenocarcinomas and that its inhibition results in a decreased tumour progression in vitro and in vivo.
in non-small cell lung cancer, SIX1-5 were associated with the greater possibility of the tumorigenesis
SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers
SIX homeobox 1 (SIX1) regulates cellular senescence by a p16INK4A (p16)-dependent mechanism.
PTH2R and its ligand TIP39 regulate intracellular calcium and influence keratinocyte differentiation
Studies strongly suggest that Six1 overexpression promotes CRC growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM. MAPK activation may be a pivotal event in Six1-associated tumor progression.
Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR-362 overexpression in cervical cancer cells. The newly identified miR-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target.
study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
miR-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells.
Pro-survival effects by NF-kappaB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Upregulation of Six1 could downregulate miR-204-5p expression.
Mutations of SIX1 gene underlie Wilms tumor recurrences.
Six1 signaling has a role in paclitaxel-dependent apoptosis in MCF-7 cell line
Data demonstrate a new role for miR30a at a key node in the myogenic regulatory gene network through controlling Six1 expression.
Data show a mechanism for Six1a and Six1b in establishing the Pax7(+) cell derived part of the fast muscle and suggest new important roles for Six1 in the regulation of the Pax7(+) muscle cell population through pSmad1/5/8 signalling.
Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear
zebrafish six1 is expressed during sensory organ development and myogenesis
six1 promotes inner hair cell fate and inhibits neuronal fate during development.
Six1a plays an essential role at the onset of fast muscle differentiation.
six1a and pax3 do not function in the same regulatory network. We proposed four putative regulatory pathways to understand how six1a distinctly interacts with either myf5 or myod during zebrafish craniofacial muscle development.
Six1 and Eya1 can both promote and arrest neuronal differentiation by activating the Notch pathway genes.
these findings establish an interaction between Pa2G4 and Six1, and demonstrate that it has an important role in the development of tissues affected in Branchiootorenal Spectrum disorder.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Eya1 and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The HD domain is important for the nuclear localization of porcine Six1 protein.
histone H4 and E2F2 bind to the -216/-28 region and play important roles in SIX1 methylation regulation during development.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, homeobox protein six1a
, homeobox protein six1b
, homeodomain transcription factor Six1b
, sine oculis homeobox homolog 1b
, sine oculis homeobox homolog 2
, Sine oculis homeobox homolog 1
, homeobox protein six1
, Homeobox protein six1a
, Sine oculis homeobox homolog 1a
, Sine oculis homeobox homolog 1b
, homeodomain transcription factor six1
, sine oculis homeobox homolog 1a