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抗Human KCNE1 抗体:
抗Rat (Rattus) KCNE1 抗体:
抗Mouse (Murine) KCNE1 抗体:
Human Polyclonal KCNE1 Primary Antibody for IF (p), IHC (p) - ABIN1385530
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
Human Monoclonal KCNE1 Primary Antibody for RNAi, ELISA - ABIN561579
Wang, Zankov, Jiang, Zhang, Henderson, Tseng: [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. in The Journal of biological chemistry 2013
TNIK (Traf2 and Nck-interacting kinase (显示 TNIK 抗体)) and MINK (Misshapen/NIKs-related kinase) MAP4K signalling kinases are integral components of both canonical and non-canonical pathways in Xenopus.
KCNE1/KCNQ1 (显示 KCNQ1 抗体) was expressed in Xenopus oocytes with and without beta-catenin (显示 CTNNB1 抗体). Confocal microscopy revealed that beta-catenin (显示 CTNNB1 抗体) enhanced the KCNE1/KCNQ1 (显示 KCNQ1 抗体) protein abundance in the cell membrane.
PIP(2) has a role in KCNE1 modulation of I(Ks) channels that may represent a common mechanism of auxiliary subunit modulation of many ion channels
characterize a new component of the early bioelectrical circuit: the potassium channel (显示 KCNAB2 抗体) KCNQ1 (显示 KCNQ1 抗体) and its accessory subunit KCNE1
phenylboronic acid (PBA) activates KCNQ1 (显示 KCNQ1 抗体)/KCNE1 complexes
Equine KV7.1 (显示 KCNQ1 抗体)/KCNE1 expressed in CHO (显示 COL11A1 抗体)-K1 cells exhibited electrophysiological properties that are overall similar to the human orthologs; however, a slower deactivation was found which could result in more open channels at fast rates.
The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (显示 KCNE4 抗体) (rs12621643) was an independent risk factor for AF among both Uygurs and Hans.
Western blotting analysis combined with these pharmacological data suggest that long-term insulin (显示 INS 抗体) treatment augments KCNQ1 (显示 KCNQ1 抗体)/KCNE1 currents by increasing KCNE1 protein expression.
KCNQ1/KCNE1 channel does not require phosphatidylinositol-4,5-bisphosphate (PIP2) or phosphatidylinositol-4-phosphate for anterograde trafficking, but is heavily reliant on PIP2 for channel function once at the plasma membrane.
The genetic variant rs426496 in AQP2 (显示 AQP2 抗体); rs591810 in AQP3 (显示 AQP3 抗体) and rs1805127, rs1805128, and rs17173510, in KCNE1 were found in patients with Meniere's disease
Meta-analysis suggests that the G38S polymorphism in the KCNE1 gene can significantly increase the risk of atrial fibrillation in both Chinese and white individuals.
Sphingomyelin synthase 1 (显示 SGMS1 抗体) positively regulates KCNQ1 (显示 KCNQ1 抗体)/KCNE1 channel density in a protein kinase D (显示 PRKD1 抗体)-dependent manner.
Receptor Species-dependent Desensitization Controls KCNQ1 (显示 KCNQ1 抗体)/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.(
KCNE1 encodes a modulator of KCNQ1 (显示 KCNQ1 抗体) and KCNH2 (显示 KCNH2 抗体) channels. Long QT syndrome (LQTS) patients with KCNE1(G38S) had a rate-dependent repolarization abnormality similar to patients with LQT2 (显示 KCNH2 抗体) and, therefore, may have a potential risk to develop lethal arrhythmias.
A stoichiometry of 4:4 between the alpha KCNE1 and the beta KCNQ1 (显示 KCNQ1 抗体)-subunits has been established.
miR-1 by anti-miR-1 inhibitor oligonucleotides alleviated the downregulation of KCNE1 and KCNB2 (显示 KCNB2 抗体), the shortening of AERP, and the increase in the IKs
The localization of KCNE1 in the RPE (显示 RPE 抗体) basal membrane, where KCNQ5 (显示 KCNQ5 抗体) was previously found to be present, suggests that this beta-subunit (显示 POLG 抗体) may contribute to M-type K(+) channels in this membrane.
The electrophysiological effects of BACE1 (显示 BACE 抗体) on KCNQ1 (显示 KCNQ1 抗体) reported here were independent of its enzymatic activity.
KCNE1 and KCNE3 (显示 Kcne3 抗体): The yin and yang of voltage-gated K(+) channel (显示 KCND3 抗体) regulation
KCNE1 and KCNE2 (显示 KCNE2 抗体), auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 (显示 BACE 抗体) and PS/gamma-secretase in cells.
In clearance studies the KCNE1 knockout mice had an increased fractional excretion of Na+, Cl-, HCO3(-) and water.
This study confirmed that KCNE1 channels are necessary for K+ secretion in developmental Saccule and Utricle in mice.
both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 (显示 KCNQ1 抗体) and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit
Findings directly implicate triggered electrical activity and spatial and temporal re-entrant mechanisms in the arrhythmogenesis observed in KCNE1 (-/-) hearts.
intestinal Cl(-) secretion is independent from KCNE1 but requires KCNQ1 (显示 KCNQ1 抗体) and in mouse pancreatic acini KCNQ1 (显示 KCNQ1 抗体) probably co-assembled with KCNE1 leads to a voltage-dependent K(+) current that might be of importance for electrolyte and enzyme secretion.
the spatial expression of minK-lacZ (显示 GLB1 抗体) in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues
The transitory transfection of kcne1 restores both Cl- and K+ swelling-activated currents, confirming the implication of KCNE1 protein in the cell-volume regulation in PCT (显示 UROD 抗体) cells in primary cultures.
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
potassium voltage-gated channel, Isk-related family, member 1
, voltage-gated potassium channel subunit MinK
, potassium voltage-gated channel subfamily E member 1
, IKs producing slow voltage-gated potassium channel subunit beta Mink
, cardiac delayed rectifier potassium channel protein
, delayed rectifier potassium channel subunit IsK
, minimal potassium channel
, potassium voltage-gated channel, Isk-related subfamily, member 1
, voltage gated potassiun channel accessory subunit
, potassium (K+) channel protein, slowly activating (Isk)
, potassium voltage-gated channel Shaw-related subfamily member 1
, delayed rectifier potassium channel protein
, slow delayed rectifier K+ channel
, voltage gated potassium channel accessory subunit cardiac splice