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IDE 抗体

(Insulin-Degrading Enzyme (IDE))
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
IDE 抗体  (AA 491-590) IDE 抗体  (AA 491-590) IDE 抗体 (AA 491-590) (ABIN723680)

IDE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

IDE 抗体  (AA 753-973) IDE 抗体  (AA 753-973) IDE 抗体 (AA 753-973) (ABIN7434305)

IDE 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

IDE 抗体  (AA 491-590) IDE 抗体  (AA 491-590) IDE 抗体 (AA 491-590) (ABIN723665)

IDE 适用: 小鼠 WB, ELISA, IHC (p), IHC (fro) 宿主: 小鼠 Polyclonal unconjugated

IDE 抗体 by Grade

Find IDE 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

IDE 抗体 by 适用

Find IDE 抗体 for a variety of species such as anti-Human IDE, anti-Mouse IDE, anti-Rat IDE. The species listed below are among those available. Click on a link to go to the corresponding products.

IDE 抗体 by 应用范围

Find IDE 抗体 validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

IDE 抗体 by 抗体来源

Find IDE 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

IDE 抗体 by 抗原表位

Find IDE 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

IDE 抗体 by 克隆形成能力

Find available monoclonal or polyclonal IDE 抗体. Click on a link to go to the corresponding products.

IDE 抗体 by 克隆

Find IDE 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

IDE 抗体 by 标记

Find IDE 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular IDE 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (6)
  • (2)
Cat. No. ABIN723680
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7434305
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN723665
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN3022285
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN561416
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), IF
Validations
  • (3)
Cat. No. ABIN7250134
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN6262443
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN334425
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), FACS
Validations
  • (4)
Cat. No. ABIN5708390
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7156344
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN3181153
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, ICC, FACS
Validations
  • (3)
Cat. No. ABIN5693119
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7307896
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN5534405
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7189242
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IDE 抗体

Radulescu, Fischer, Stange, Schulze: "Promoting scientific standards in Germany." in: Science (New York, N.Y.), Vol. 328, Issue 5976, pp. 307, (2010) (PubMed).

Radulescu, Poznic, Pavelic: "Complex formation between metabolic enzymes in tumor cells: unfolding the MDR1-IDE paradigm." in: Molecular cancer therapeutics, Vol. 8, Issue 11, pp. 3171, (2009) (PubMed).

Kim, Hersh, Leissring, Ingelsson, Matsui, Farris, Lu, Hyman, Selkoe, Bertram, Tanzi: "Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7825-32, (2007) (PubMed).

Zhao, Xiang, Haroutunian, Buxbaum, Stetka, Pasinetti: "Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease." in: Neurobiology of aging, Vol. 28, Issue 6, pp. 824-30, (2007) (PubMed).

Vepsäläinen, Parkinson, Helisalmi, Mannermaa, Soininen, Tanzi, Bertram, Hiltunen: "Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population." in: Journal of medical genetics, Vol. 44, Issue 9, pp. 606-8, (2007) (PubMed).

Radulescu, Hufnagel, Luppa, Hellebrand, Kuo, Rosner, Harbeck, Giersig, Meindl, Schmitt, Weirich: "Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels." in: International journal of oncology, Vol. 30, Issue 1, pp. 73-80, (2006) (PubMed).

Aliases for IDE 抗体

insulin degrading enzyme (IDE) 抗体
insulin-degrading enzyme (ide) 抗体
insulin-degrading enzyme (LOC591315) 抗体
insulin-degrading enzyme (CC1G_01115) 抗体
insulin-degrading enzyme (Bm1_26615) 抗体
insulin-degrading enzyme (PTRG_10875) 抗体
metallopeptidase (SJAG_01430) 抗体
insulin-degrading enzyme (EBI_21700) 抗体
insulin-degrading enzyme (VDBG_06702) 抗体
insulin-degrading enzyme (LOAG_08082) 抗体
insulin-degrading enzyme (PGTG_04982) 抗体
insulin-degrading enzyme (Tsp_00424) 抗体
insulin degrading enzyme (Ide) 抗体
1300012G03Rik 抗体
4833415K22Rik 抗体
AA675336 抗体
AI507533 抗体
IDE 抗体
INSDEGM 抗体
INSULYSIN 抗体
zgc:162603 抗体
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