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Human VEGFR2 Protein expressed in Insect Cells - ABIN809790
Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013
Thioredoxin-interacting protein (TXNIP (显示 TXNIP 蛋白)) is highly induced in retinal vascular endothelial cells under diabetic conditions. Data (including data from studies using knockout mice) suggest that TXNIP (显示 TXNIP 蛋白) in retinal vascular endothelial cells plays role in diabetic retinal angiogenesis via VEGF (显示 VEGFA 蛋白)/VEGFR2 and Akt (显示 AKT1 蛋白)/mTOR (显示 FRAP1 蛋白) signaling.
Inhibition of FPR1 (显示 FPR1 蛋白) and/or NADPH oxidase (显示 NOX1 蛋白) functions prevents VEGFR2 transactivation and the triggering of the downstream signalling cascades.
VEGFA (显示 VEGFA 蛋白) activates VEGFR1 (显示 FLT1 蛋白) homodimers and AKT (显示 AKT1 蛋白), leading to a cytoprotective response, whilst abluminal VEGFA (显示 VEGFA 蛋白) induces vascular leakage via VEGFR2 homodimers and p38 (显示 CRK 蛋白)
association of rs519664[T] in TTC39B on 9p22 with endometriosis, is reported.
VEGF (显示 VEGFA 蛋白), VEGFR2 and GSTM1 (显示 GSTM1 蛋白) polymorphisms in outcome of multiple myeloma patients treated with thalidomide-based regimens
In the in vitro tests, JFD-WS effectively inhibited HUVEC proliferation, migration, tube formation and VEGFR2 phosphorylation. Additionally, JFD-WS inhibited the formation of blood vessels in chick chorioallantoic membrane. While inhibiting the xenograft tumor growth in experimental mice, JFD-WS decreased the plasma MUC1 (显示 MUC1 蛋白) levels
The effects of Platelet-rich plasma on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 (显示 CD34 蛋白) expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin
metformin's dual effect in hyperglycemia-chemical hypoxia is mediated by direct effect on VEGFR1 (显示 FLT1 蛋白)/R2 leading to activation of cell migration through MMP16 (显示 MMP16 蛋白) and ROCK1 (显示 ROCK1 蛋白) upregulation, and inhibition of apoptosis by increase in phospho-ERK1/2 and FABP4 (显示 FABP4 蛋白), components of VEGF (显示 VEGFA 蛋白) signaling cascades
Single nucleotide polymorphism of VEGFR2 is associated with relapse in gastroenteropancreatic neuroendocrine neoplasms.
Our data showed that ampelopsin inhibited angiogenesis with no cytotoxicity by suppressing both VEGFR2 signaling and HIF-1alpha (显示 HIF1A 蛋白) expression. These results suggest that Hovenia dulcis Thunb. and its active compound ampelopsin exhibit potent antiangiogenic activities and therefore could be valuable for the prevention and treatment of angiogenesis-related diseases including cancer.
significant increase in VEGFR-2 promoter activity after partial hepatectomy
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are required for the hematopoietic and cardiac fate divergence of mouse embryonic stem cells. Deletion of IP3Rs (IP3R-tKO) reduced Flk1+/PDGFRalpha- hematopoietic mesoderm, c-Kit+/CD41+ hematopoietic progenitor cell population, and the colony-forming unit activity, but increased cardiac progenitor markers as well as cardiomyocytes.
Peli1 (显示 PELI1 蛋白) is a proangiogenic molecule that acts downstream of VEGF (显示 VEGFA 蛋白)-Flk-1 and restores angiogenesis and enhances skin flap (显示 ALOX5AP 蛋白) survivability
KDR/Flk-1 expression was revealed in mononuclear cells of the necrotic area (macrophages and fibroblast cells). The distribution of KDR/Flk-1 remained practically unchanged with lengthening of the postinfarction period (more than 7 days).
By E10.5, both Sox7 (显示 SOX7 蛋白) complete knockout and FLK1-specific deletion of Sox7 (显示 SOX7 蛋白) lead to widespread vascular defects. In contrast, while SOX7 (显示 SOX7 蛋白) is expressed in the earliest specified blood progenitors, the VAV (显示 VAV1 蛋白)-specific deletion of Sox7 (显示 SOX7 蛋白) does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 (显示 SOX7 蛋白) in vasculogenesis and angiogenesis during embryonic development.
JAM-C (显示 JAM3 蛋白) plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress.
Genetic depletion experiments revealed that VEGFR2, but not VEGFR3 (显示 FLT4 蛋白), is indispensable for maintenance of thyroid vascular integrity. Notably, blockade of VEGF-A (显示 VEGFA 蛋白) or VEGFR2 not only abrogated vascular remodeling but also inhibited follicular hypertrophy, which led to the reduction of thyroid weights during goitrogenesis.
Eriocalyxin B inhibited breast tumor angiogenesis by suppressing VEGFR-2 signaling.
transgenic mice may serve as valid models for the validation of novel therapies blocking the VEGFR-2 signaling pathway in hemangioma-like lesions and other vascular diseases
found that WT1 (显示 WT1 蛋白) and KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries. Furthermore, WT1 (显示 WT1 蛋白) bound to the Kdr promoter in the chromatin of embryonic testes and ovaries. KDR signaling represses the testis-promoting gene Sox9 (显示 SOX9 蛋白) in embryonic XX gonads
Here we demonstrate that VEGF (显示 VEGFA 蛋白)-165 mediates MSC (显示 MSC 蛋白) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (显示 SOX18 蛋白), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS stimulation via PI3K, calpain proteases, and SIRT1 (显示 SIRT1 蛋白)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (显示 FLT1 蛋白)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (显示 MCAM 蛋白) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (显示 VEGFA 蛋白) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (显示 SCN5A 蛋白) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (显示 FLT1 蛋白) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF (显示 VEGFA 蛋白) ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (显示 VEGFA 蛋白)/Flk-1/Flt-1 (显示 FLT1 蛋白) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA 蛋白), pro-MMP-9 (显示 MMP9 蛋白), MMP-2 (显示 MMP2 蛋白), VEGFR-1 (显示 FLT1 蛋白), VEGFR-2, and TIMP-1 (显示 TIMP1 蛋白), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (显示 TGFB1 蛋白) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF (显示 VEGFA 蛋白) receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (显示 LGALS1 蛋白) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (显示 LGALS1 蛋白) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (显示 MMP1 蛋白) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (显示 F2R 蛋白) and activation of NF-kappaB (显示 NFKB1 蛋白)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (显示 ARF1 蛋白) to promote endothelial nitric-oxide synthase (显示 NOS3 蛋白) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (显示 VEGFA 蛋白) and bFGF (显示 FGF2 蛋白) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (显示 AKT1 蛋白) and endothelial nitric-oxide synthase (eNOS (显示 NOS3 蛋白))
Placenta growth factor (显示 PGF 蛋白) expression is regulated by both VEGF (显示 VEGFA 蛋白) and hyperglycaemia via VEGFR-2.
These results indicate that VEGF-C (显示 VEGFC 蛋白)-induced MSC (显示 MSC 蛋白) osteogenesis is mediated through VEGFR2 and VEGFR3 (显示 FLT4 蛋白), and followed the activation of the ERK (显示 MAPK1 蛋白)/RUNX2 (显示 RUNX2 蛋白) signaling pathway.
High VEGFR2 expression is associated with retinal neovascularization.
ghrelin (显示 GHRL 蛋白) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (显示 VEGFA 蛋白) and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (显示 CCL2 蛋白) expression at an advanced stage of atherosclerosis in rabbits
Antenatal intratracheal VEGF (显示 VEGFA 蛋白) administration was associated with an increase in Flk-1 immunoreactivity.
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (显示 RBPJ 蛋白)-mediated venous repression.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
fetal liver kinase 1
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, vascular endothelial growth factor receptor 2
, VEGF receptor-2
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, flk-1 receptor
, protein-tyrosine kinase
, flk-1 type VEGF receptor
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B