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|抗原||Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) 抗体|
|抗原表位||AA 342-361, Middle Region 其他选择|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This TRKA antibody is un-conjugated 其他选择|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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TRKA抗体详情TRKA目标详情 使用细节 贮存及处理 References for anti-TRKA antibody (ABIN3044367) 图像
|原理||Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.|
|交叉反应 （详细）||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Protein Name: High affinity nerve growth factor receptor
|纯化方法||Immunogen affinity purified.|
|免疫原||A synthetic peptide corresponding to a sequence in the middle region of human TrkA(342-361aa RHGCLRLNQPTHVNNGNYTL), identical to the related rat and mouse sequences.|
TRKA目标详情TRKA抗体详情 使用细节 贮存及处理 References for anti-TRKA antibody (ABIN3044367) 图像 回页首
|别名||NTRK1 (NTRK1 Antibody 摘要)|
Trk A(Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor(NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA(NTRK1), TRKB(NTRK2), and TRKC(NTRK3). TRKA, TRKB, and TRKC are specific for or "preferred by" NGF, NTF4(Neurotrophin-4) and BDNF, and NTF3(Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA(NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform(s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al.(1996) concluded that defects in TRKA cause CIPA(Congenital insensitivity to pain with anhidrosis) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system.
Synonyms: CIPA antibody|DKFZp781I14186 antibody|gp140trk antibody|High affinity nerve growth factor receptor antibody|High affinity nerve growth factor receptor precursor antibody|MTC antibody|neurotrophic tyrosine kinase receptor type 1 antibody|Ntrk 1 antibody|Ntrk1 antibody|NTRK1_HUMAN antibody|Oncogene TRK antibody|p140 TrkA antibody|p140-TrkA antibody|TRK 1 antibody|Trk A antibody|TRK antibody|Trk-A antibody|TRK1 antibody|TRK1 transforming tyrosine kinase protein antibody|TRK1-transforming tyrosine kinase protein antibody|Tropomyosin-related kinase A antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Tyrosine Receptor Kinase A antibody
|途径||RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process|
使用细节TRKA抗体详情 TRKA目标详情 贮存及处理 References for anti-TRKA antibody (ABIN3044367) 图像 回页首
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
贮存及处理TRKA抗体详情 TRKA目标详情 使用细节 References for anti-TRKA antibody (ABIN3044367) 图像 回页首
|溶解方式||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|缓冲液||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|储存液||Thimerosal (Merthiolate), Sodium azide|
|注意事项||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-TRKA antibody (ABIN3044367)TRKA抗体详情 TRKA目标详情 使用细节 贮存及处理 图像 回页首
Li, Ma, Yi, Wang, Li, Liu, Sun, Chen, Yu, Li, Chen, Zhou: "The interactions between nerve growth factor and gonadotrophins in bovine oviduct." in: Animal reproduction science, Vol. 149, Issue 3-4, pp. 117-23, 2014
Li, Zhang, Zou, Xia, Bao: "Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis." in: Reproductive biology and endocrinology : RB&E, Vol. 9, pp. 30, 2011
图像TRKA抗体详情 TRKA目标详情 使用细节 贮存及处理 References for anti-TRKA antibody (ABIN3044367) 回页首