anti-小鼠 TEK 抗体 for Immunofluorescence (Paraffin-embedded Sections)

Recommended TEK Antibody

抗原
TEK Tyrosine Kinase, Endothelial (TEK) 抗体
  • TEK
  • DKFZp469E064
  • AA517024
  • Cd202b
  • Hyk
  • Tie2
  • tie-2
  • CD202B
  • TIE-2
  • TIE2
  • VMCM
  • VMCM1
  • Tie-2
  • tie2
  • TEK receptor tyrosine kinase
  • angiopoietin-1 receptor
  • TEK tyrosine kinase, endothelial
  • TEK
  • LOC100408334
  • tek
  • Tek
抗原表位
AA 450-500
28
25
22
20
16
14
11
10
10
8
8
8
6
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
287
162
99
9
8
宿主

235
64
10
3
2
1
克隆类型
多克隆
标记
This TEK antibody is un-conjugated
21
14
10
8
8
8
8
8
8
7
6
4
4
4
4
4
4
1
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
172
128
69
52
48
21
21
19
16
12
8
6
6
3
选项

Available images

产品编号 ABIN674649
$ 329.45
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
1 ABIN1708151 IF (p) Cy7 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1708152 IF (p) Cy7 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1706340 IF (p) Cy5.5 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1706341 IF (p) Cy5.5 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1709962 IF (p) FITC Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1709963 IF (p) FITC Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1697134 IF (p) Alexa Fluor 555 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1697135 IF (p) Alexa Fluor 555 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1695310 IF (p) Alexa Fluor 488 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1695311 IF (p) Alexa Fluor 488 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1693491 IF (p) Alexa Fluor 350 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1693492 IF (p) Alexa Fluor 350 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1704383 IF (p) Cy5 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1704382 IF (p) Cy5 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1702572 IF (p) Cy3 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN1702571 IF (p) Cy3 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1698945 IF (p) Alexa Fluor 647 Rabbit IgG pTyr1102 Polyclonal 0
1 ABIN1698946 IF (p) Alexa Fluor 647 Rabbit IgG pTyr1108 Polyclonal 0
1 ABIN917724 IF (p) Alexa Fluor 488 Rabbit IgG AA 450-500 Polyclonal 0
1 ABIN917723 IF (p) Alexa Fluor 555 Rabbit IgG AA 450-500 Polyclonal 0

General

抗原 TEK Tyrosine Kinase, Endothelial (TEK) 抗体
抗原表位 AA 450-500
(28), (25), (22), (20), (16), (14), (11), (10), (10), (8), (8), (8), (6), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(287), (162), (99), (9), (8)
宿主
(235), (64), (10), (3), (2), (1)
克隆类型
多克隆
标记 This TEK antibody is un-conjugated
(21), (14), (10), (8), (8), (8), (8), (8), (8), (7), (6), (4), (4), (4), (4), (4), (4), (1)
应用范围 Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(172), (128), (69), (52), (48), (21), (21), (19), (16), (12), (8), (6), (6), (3)
Pubmed 4个引用可参考
Supplier

TEK抗体详情

TEK目标详情 使用细节 贮存及处理 References for anti-TEK antibody (ABIN674649) 图像
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synthetic peptide derived from human Tie2
亚型 IgG
Plasmids, Primers & others

TEK目标详情

TEK抗体详情 使用细节 贮存及处理 References for anti-TEK antibody (ABIN674649) 图像 回页首
抗原
别名 Tie2/Cd202b (TEK Antibody 摘要)
背景

Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.

Subcellular location: Extracellular

Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD22B, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p14 TEK, TEK

基因ID 7010
UniProt Q02763
途径 RTK signaling, Growth Factor Binding

使用细节

TEK抗体详情 TEK目标详情 贮存及处理 References for anti-TEK antibody (ABIN674649) 图像 回页首
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
限制 仅限研究用

贮存及处理

TEK抗体详情 TEK目标详情 使用细节 References for anti-TEK antibody (ABIN674649) 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months

References for anti-TEK antibody (ABIN674649)

TEK抗体详情 TEK目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Li, Liu, Liu, Wang, Zhang, Chen, Hui: "Expression of angiopoietins in central nervous system hemangioblastomas is associated with cyst formation." in: Neuroscience letters, Vol. 639, pp. 120-125, 2017 Method employed by authors: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human). Further details: Sample: tumor

Xiang, Hu, Shen, Liu, Hua, Zan, Zu, Cui, Ye: "Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats." in: Neuroscience letters, Vol. 644, pp. 62-66, 2017 Method employed by authors: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: brain

Tekari, Chan, Sakai, Grad, Gantenbein: "Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells." in: Stem cell research & therapy, Vol. 7, Issue 1, pp. 75, 2016 Method employed by authors: Flow Cytometry (FACS) (Sample species: Cow (Bovine)).

Zhao, Hu, Xiang, Gu, Jin, Hua, Zhang, Liu, Zan, Zhang, Zu, Yang, Shi, Zhu, Xu, Cui, Ye: "Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke." in: Brain research, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Brain

图像

TEK抗体详情 TEK目标详情 使用细节 贮存及处理 References for anti-TEK antibody (ABIN674649) 回页首
厂商提供的图像
Immunohistochemistry (IHC) image for anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 450-500) antibody (ABIN674649) Formalin-fixed and paraffin embedded rat retina tissue labeled with Anti TIE2/CD202b ...