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|抗原||Met Proto-Oncogene (MET) 抗体|
|抗原表位||pTyr1234, pTyr1235 其他选择|
|适用||人, 小鼠 其他选择|
|标记||This MET antibody is un-conjugated 其他选择|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|Supplier||Log in to see|
MET抗体详情MET目标详情 使用细节 贮存及处理 图像
|特异性||This antibody detects MET/HGFR pTyr1234/1235.|
|交叉反应 （详细）||Species reactivity (tested):Human and Mouse.|
|产品特性||Synonyms: Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met,Met proto-oncogene tyrosine kinase|
|纯化方法||Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|免疫原||This monoclonal antibody is generated from mice immunized with a KLH conjugatedsynthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met andresidues both Tyr1234 and Tyr1235 are phosphorylated.|
MET目标详情MET抗体详情 使用细节 贮存及处理 图像 回页首
|别名||HGF Receptor (MET Antibody 摘要)|
|背景||MET/HGFR is a receptor for hepatocyte growth factor, with tyrosine-protein kinase activity. The MET/HGFR Type I membrane protein contains 1 Sema domain and consists of a heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. In the fully processed c-Met product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains as well as sites of tyrosine phosphorylation. Two isoforms for the protein have been described. Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. MET is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC), also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.Synonyms: HGF/SF receptor, Hepatocyte growth factor receptor, MET, Met proto-oncogene tyrosine kinase, Scatter factor receptor, c-Met|
|途径||RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor|
使用细节MET抗体详情 MET目标详情 贮存及处理 图像 回页首
ELISA: 1/1,000. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理MET抗体详情 MET目标详情 使用细节 图像 回页首
|缓冲液||PBS with 0.09 % (W/V) Sodium Azide as preservative, 0.09 % (W/V) Sodium Azide|
|注意事项||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存条件||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
图像MET抗体详情 MET目标详情 使用细节 贮存及处理 回页首