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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398
Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011
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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN803884
de Waal, Leal, García-López, Liarte, de Jonge, Hinfray, Brion, Schulz, Bogerd: Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis. in The Journal of endocrinology 2009
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Human IGF1 Protein expressed in - ABIN1111672
Devi, Dixit: Clinical Evaluation of Insulin like Growth Factor-I and Vascular Endothelial Growth Factor with Alloplastic Bone Graft Material in the Management of Human Two Wall Intra-Osseous Defects. in Journal of clinical and diagnostic research : JCDR 2016
Human IGF1 Protein expressed in Insect cells (Sf9) - ABIN935729
Ablonczy, Crosson: VEGF modulation of retinal pigment epithelium resistance. in Experimental eye research 2007
Bio informatics analysis of 982 lung cancer patients revealed that higher expression of TNF- alpha (显示 TNF 蛋白) was associated with low risk of cancer progression while overexpression of IGF-1 was correlated with high risk. Collectively, these results reveal that the cytokines in the tumor microenvironment differentially modulate radiation therapy through a variety of signaling mechanisms.
Data suggest that lower IGF1 serum levels in aging are associated with lower handgrip strength and worse physical performance, but less recurrent falls, especially in men. This longitudinal study was conducted in the Netherlands.
Data suggest that R1353H point mutation constitutes an activating IGF1R variant that can result in extreme tall height with very low levels of serum IGFI; the mutation was observed in proband, his mother, and his 3 sons, however, only the proband (43 y/o) and eldest son (18 y/o) exhibit extreme tall height. [CASE REPORT]
IGF-1 treatment activated protein kinase B (AKT (显示 AKT1 蛋白)), which may inhibit autophagy via the AKT (显示 AKT1 蛋白)/mammalian target of rapamycin (显示 FRAP1 蛋白) signaling pathway. Following inhibition of autophagy, drug resistant cells became sensitive to apoptosis induced by 5-fluorouracil.
Consistent with its enhanced expression in Laron syndrome, we provide evidence that TXNIP (显示 TXNIP 蛋白) gene expression is negatively regulated by IGF1.
In elderly women with low-energy distal radius fractures, an association between IGF1 and lowest measures of bone mineral density was found, indicating that low IGF1 could be an indirect risk factor for fractures.
Expression of miR (显示 MLXIP 蛋白)-30a-3p was significantly increased in the placentas of patients with preeclampsia. miR (显示 MLXIP 蛋白)-30a-3p might be involved in the pathogenesis of preeclampsia by targeting IGF-1 and regulating the invasion and apoptosis of trophoblast cells.
results suggest that the different isoforms of the PI3K (显示 PIK3CA 蛋白) p110 subunit could be therapeutic targets for primary and metastatic colon cancer and that regulation of the NRD1 (显示 NRD1 蛋白)/ADAM signaling pathway controls lipogenesis-mediated EMT (显示 ITK 蛋白) in IGF-1-stimulated colon cancer cells.
Demonstrate the uptake of fluorescently labeled IGF-I into skeletal growth plates of live mice using multiphoton microscopy.
Study provides evidence that IGF-1/IGF-1R (显示 IGF1R 蛋白)/hsa (显示 CD24 蛋白)-let-7c axis can control the odonto/osteogenic differentiation of IGF-1-treated stem cells from apical papilla via the regulation of JNK (显示 MAPK8 蛋白) and p38 MAPK (显示 MAPK14 蛋白) signaling pathways.
Combined treatment with electrical stimulation and insulin-like growth factor-1 promotes bone regeneration in vitro.
Enteric neural stem cells expressing IGF1 has been proposed as a novel cellular therapy for Hirschsprung's Disease tested in a mouse model.
Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normoglycemic conditions nor in diabetes.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (显示 INS 蛋白)/InsR (显示 INSR 蛋白) and IGF-1/IGF-1R (显示 IGF1R 蛋白) signaling. Insulin (显示 INS 蛋白) therapy in the early stage may delay diabetic gastroparesis
these results indicate that IGF-I induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53 (显示 TP53 蛋白)-dependent manner and that IGF-I may be applied to treat nonalcoholic steatohepatitis and cirrhosis.
IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective and antiapoptotic proteins.
Inhibition of mammalian target of rapamycin (mTOR (显示 FRAP1 蛋白)) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1 (显示 CCL2 蛋白), CCL5/RANTES (显示 CCL5 蛋白) and IGF-1 in vitro.
These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length.
The data demonstrate that miR (显示 MLXIP 蛋白)-206 sensitizes nasopharyngeal carcinoma cells to irradiation by targeting IGF1, highlighting the therapeutic potential of miR (显示 MLXIP 蛋白)-206 in nasopharyngeal carcinoma radiosensitization.
the dipeptide Pro-Asp (显示 ASIP 蛋白) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (显示 FRAP1 蛋白) and PPARg (显示 PPARG 蛋白). In summary, PPARg (显示 PPARG 蛋白) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (显示 HGF 蛋白) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (显示 CEBPA 蛋白) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (显示 LEP 蛋白) on cell proliferation/apoptosis, MAP kinase (显示 MAPK1 蛋白) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (显示 LEP 蛋白). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (显示 SLC23A2 蛋白) is expressed in IVD (显示 IVD 蛋白) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (显示 INS 蛋白) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (显示 GH1 蛋白)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (显示 INS 蛋白)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (显示 TNF 蛋白).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.
Study demonstrated that IGF-I can stimulate egfr (显示 EGFR 蛋白) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (显示 EGF 蛋白), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (显示 PGC 蛋白) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (显示 IGFBPI 蛋白)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (显示 AKT1 蛋白) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (显示 BMP4 蛋白), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (显示 XBP1 蛋白) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (显示 AKT1 蛋白) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (显示 STAT5A 蛋白) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (显示 POU1F1 蛋白) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (显示 LHCGR 蛋白) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (显示 INS 蛋白)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (显示 MAPK1 蛋白)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (显示 IGFBP3 蛋白)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (显示 INSR 蛋白) and/or insulin-like growth factor-1 receptor (显示 IGF1R 蛋白) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (显示 IGF1R 蛋白) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (显示 HSP90AB1 蛋白) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (显示 MSTN 蛋白) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A