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Mouse (Murine) FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN809712
McCoy, Golden, Doll, Yang, Kaba, Burkhard, Lanar: Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. in Malaria journal 2013
Human FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN413275
Staron, Yang, Liu, Li, Shen, Zúñiga-Pflücker, Aguila, Goldschneider, Li: gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. in Blood 2010
Human FLT3LG Protein expressed in - ABIN1111450
McGill, Tomco, Ondrasik, Belknap, Dwyer, Quinlan, Kircher, Andam, Brown, Claxton, Barth: Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia. in Phytotherapy research : PTR 2018
Flt3L could enhance the efficacy of immune checkpoint blockades in glioblastoma via expanding CD103 (显示 ITGAE 蛋白)+ dendritic cells and downstream antitumor immune response.
Intratumoral administration of the STING agonist cyclic di-GMP (显示 NT5C2 蛋白) (CDG) or Flt3 Ligand (Flt3L) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP (显示 DPT 蛋白)-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity
both Flt3 ligand (FL) and IL-7 (显示 IL7 蛋白) regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D (显示 LY6D 蛋白)(+)CD135 (显示 FLT3 蛋白)(+)CD127 (显示 IL7R 蛋白)(+)CD19 (显示 CD19 蛋白)(-) progenitors and IL-7 (显示 IL7 蛋白) by providing survival signals to these progenitors
Data show that FLT3 ligand (FLT3L) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (显示 ATXN1 蛋白)(+)c-Kit(+) [LSK (显示 LCK 蛋白)] cells via CXCR4 (显示 CXCR4 蛋白) receptor regulation.
these results demonstrate that the lack of Flt3L mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells
this study shows that ionizing radiation induces a decrease of CD8 (显示 CD8A 蛋白)+ dendritic cells and Th1 (显示 HAND1 蛋白)/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression
may be mediated by Flt3L- and MMP-9 (显示 MMP9 蛋白)-dependent mobilization of dendritic cells
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L.
Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (显示 CSF3 蛋白), Flt3 (显示 FLT3 蛋白)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
The cytokine Fms-like tyrosine kinase 3 ligand is an important regulator of hematopoiesis. Its receptor, Flt3 (显示 FLT3 蛋白), is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. [review]
Results elucidated a novel resistance mechanism that FL attenuated inhibitory effects of FLT3 (显示 FLT3 蛋白) inhibitors mainly through the activation of Wt-FLT3 (显示 FLT3 蛋白), not mutated FLT3 (显示 FLT3 蛋白) in acute myeloid leukemia (显示 BCL11A 蛋白).
it is likely that TGFbeta1 (显示 TGFB1 蛋白) and FL, both abundantly produced by bone marrow stromal cells, function in a coordinated manner to render mixed-lineage leukemia gene-rearranged acute lymphoblastic leukemia cells chemoresistant
Pre-treatment serum levels of FLT3 (显示 FLT3 蛋白)-L were higher than controls. FLT3 (显示 FLT3 蛋白)-L correlated positively with all soluble angiogenic factors, as well with bone marrow microvascular density. Post-treatment FLT3 (显示 FLT3 蛋白)-L decreased significantly in responders to therapy.
The immunohistochemical expression of caveolin-1 (显示 CAV1 蛋白) and podocalyxin (显示 PODXL 蛋白) in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
The Flt3L/CD135 (显示 FLT3 蛋白) axis is active in rheumatoid arthritis
Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells
Administration of the hematopoietic growth factor (显示 IL-3 蛋白) Flt3L to human subjects increases the frequency and absolute number of Treg cells.
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE\; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010
, flt3 ligand
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand