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Human FGF1 Protein expressed in Human - ABIN2452191
Zakrzewska, Marcinkowska, Wiedlocha: FGF-1: from biology through engineering to potential medical applications. in Critical reviews in clinical laboratory sciences 2008
Human FGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2001899
Hebart, Einsele: Diagnosis and treatment of cytomegalovirus infection. in Current opinion in hematology 1999
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Gas5 regulated proliferation and apoptosis in growth plate by controlling FGF1 expression via miR (显示 MLXIP 蛋白)-21 regulation.
Modification of the heparin-binding region of FGF1 significantly improves the cardioprotective efficacy, even in the presence of heparin, identifying a novel FGF ligand available for therapeutic use in ischemic heart disease.
FGF1 protects neuroblastoma cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.
Specific heparin derivatives molecular recognition patterns by FGF1 have been reported.
Multiple stepwise linear regression analysis found serum level of FGF1 was dependent on anti-diabetic drugs, hemoglobin A1C, body mass index and sex. Serum level of FGF1 is associated with the decreased risk of obesity in human.
Our study suggests that the genetic variants of FGF1 rs34011, more so than FGF2 (显示 FGF2 蛋白) rs2922979, may play a role in PE pathogenesis in Tunisian women.
FGF1 and 2 strongly prevent the osteogenic commitment and differentiation of hBMSCs.
Transfected FGF1 promotes angiogenic proliferation.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1/fibroblast growth factor receptor 4 (显示 FGFR4 蛋白) signaling in the progression of ovarian cancer. the expression level of Snail1 (显示 SNAI1 蛋白) and MMP3 (显示 MMP3 蛋白) was reduced, while the expression level of E-cadherin (显示 CDH1 蛋白) increased
Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells.
FGF1 and FGF7 (显示 FGF7 蛋白) may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
Western Blot analysis revealed a decrease in FGF-1 protein expression after day 40 in the porcine umbilical cord during pregnancy
TUG1 knockdown ameliorates atherosclerosis by modulating FGF1 via miR (显示 MLXIP 蛋白)-133a in ApoE (显示 APOE 蛋白) knockout mice.
Fibroblast growth factor (FGF1 and FGF2 (显示 FGF2 蛋白)), but not vascular endothelial growth factor (VEGF (显示 VEGF 蛋白)) rescued Psen1 (显示 PSEN1 蛋白)-/- cells from serum starvation induced apoptosis.In the absence of serum, FGF2 (显示 FGF2 蛋白) immunoreactivity was distributed diffusely in cytoplasmic and nuclear vesicles of wt and Psen1 (显示 PSEN1 蛋白)-/- cells, as levels of FGF2 (显示 FGF2 蛋白) in nuclear and cytosolic fractions were not significantly different.
Suboptimal FGFR (显示 FGFR2 蛋白) activation by a weak FGF1-FGFR (显示 FGFR2 蛋白) dimer is sufficient to evoke a metabolic response, whereas full FGFR (显示 FGFR2 蛋白) activation by stable and sustained dimerization is required to elicit a mitogenic response.
the HDAC3 (显示 HDAC3 蛋白)-N-CoR (显示 NCOR1 蛋白) corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1 (显示 CRTC1 蛋白), phosphorylated CREB (显示 CREB1 蛋白), and histone acetyltransferase CBP (显示 CREBBP 蛋白) induces transient transcription.
lncRNA-Map2k4 is the target gene of miR-199a, and its down-regulation promotes miR-199a expression in neurons. miR-199a targeted regulation of FGF1 expression in neurons.
clearly demonstrate the different specificity of FGF12 (显示 FGF12 蛋白)-FGFR1c2 and FGF22 (显示 FGF22 蛋白)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (显示 KLB 蛋白) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (显示 FGFR2 蛋白)-betaKlotho (显示 KLB 蛋白) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
fibroblast growth factor 1 (FGF1) to be synergistically induced by heat shock and wounding.
Data suggest that Fgf1-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1) and Fgfr1 (fibroblast growth factor receptor 1 (显示 FGFR1 蛋白)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (显示 LEP 蛋白)).
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
beta-endothelial cell growth factor
, endothelial cell growth factor, alpha
, endothelial cell growth factor, beta
, fibroblast growth factor 1
, heparin-binding growth factor 1
, EDGF II
, acidic eye-derived growth factor II
, acidic fibroblast growth factor
, endothelial cell growth factor beta and alpha chains
, endothelial growth factor
, fibroblast growth factor, acidic
, heparin-binding growth factor 1 isoform 1 proprotein
, Heparin-binding growth factor 1
, acidic fgf
, acidic fibroblast growth factor, aFGF
, alpha-endothelial cell growth factor
, endothelial cell growth factor
, fibroblast growth factor 1 (acidic)
, Fibroblast growth factor 1 (heparin binding)
, Acidic fibroblast growth factor