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Mouse (Murine) Ephrin B2 Protein expressed in Human Cells - ABIN2008042
Flanagan, Vanderhaeghen: The ephrins and Eph receptors in neural development. in Annual review of neuroscience 1998
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It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1.
Production of inflammatory cytokines was inhibited by Ti particles through bidirectional signals. Addition of ephB4Fc inhibited the osteoclastmediated formation of Ti particles via bidirectional ephrinB2/ephB4 signaling. Activation of this bidirectional signaling pathway may be a potential clinical treatment for osteolysis surrounding prostheses.
Results show that early but not late post conditioning hippocampal protein synthesis is necessary for the formation of remote memory and provide the first evidence of a possible involvement of EphrinB2 in neuronal plasticity in the anterior cingulate cortex.
GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse.
Results show that EfnB2 plays a previously unrecognized role as a principal regulator of hematopoiesis from the dorsal aorta and embryonic stem cells by controlling the emergence of hemogenic endothelial cells. During vascular development, EfnB2 is essential for the proper sorting of arterial and venous-fated endothelium into distinct arterial and venous vascular beds.
Data reveal that ephrinB2 and ephrinB3 signaling is required to control progenitor identities in the ventral spinal cord.
that expression of EFNB1 and EFNB2 is implicated in Th cell differentiation and migration to inflammatory sites in both EAE and MS
As endothelial progenitor cells (EPCs)derived from mouse bone marrow were cultured on substrates of increasing stiffness, the mRNA and protein levels of the specific arterial endothelial cell marker ephrinB2 were found to increase, while the expression of the venous marker EphB4 decreased
an autonomous receptor-like role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1/B2/B3) conditional triple mutant (TM(lz)) mice, is reported.
During urogenital development, different modes of Eph/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.
Male Efnb2 knockout mice presented reduced blood pressure. Region from aa 313 to aa 331 of EFNB2 was essential for reverse signaling regulating VSMC contractility.
Suggest role for ephrinB2/EphB4 signaling in the maintenance of neurovascular homeostasis and show that EphrinB2 activation promotes vascular repair mechanisms and reduces brain swelling after mild cerebral ischemia.
The Eph/ephrin-B2-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.
Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade
The Netrin-1 and ephrin-B2 synergistic growth cone responses involve the potentiation of Src family kinase signaling, a common effector of both pathways.
in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development
the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.
our study uncovered a novel cell autonomous role for ephrinB2 in lateral motor column motoneurons
These data indicate that ephrinB2/EphB4 signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.
EfnB2 is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EfnB2 signaling repressing JNK3 activity via STAT1.
disruption of cochlear signalling results in supporting cell translocation into hair cell layers
This is the novel report describing to demonstrate that the Runx2 expression of MSC is synergistically influenced by the hydrogels elasticity and their manner of ephrinB2 immobilized.
the binding of the viral attachment protein G to its host receptor ephrinB2 was studied and showed monomeric and dimeric receptors activate distinct conformational changes in G.
results suggest that ephrin-B2 overexpression and activation of the ephrin-B2 reverse signaling pathway in tumor microenvironment in OSCC facilitates progression and lymph node metastasis via enhancement of malignant potential and interaction with surrounding cells
Proteomic analysis of their secretome reveals a signature, including ephrin-B2, that predicts decreased survival of glioma patients. We find that ephrin-B2 is an important pro-angiogenic tenascin-C effector.
In human glioblastoma stem-like cells-derived orthotopic xenografts, EFNB2 knock-down blocked tumour initiation and treatment of established tumours with ephrin-B2-blocking antibodies suppressed progression.
roles in stabilizing vascular-like structures generated by stem cells from apical papilla (SCAPs) and umbilical vein endothelial cells (HUVECs)
High EFNB2 expression is associated with preeclampsia.
Inhibition of EphB4 forward signaling using soluble EphB4 protein fused with murine serum albumin failed to affect eRMS model tumor progression, but did moderately slow progression in murine aRMS
Study shows that EFNB2 is overexpressed in head and neck squamous cell carcinoma, pancreatic adenocarcinoma, and urothelial bladder carcinoma, and its overexpression correlates with poor survival of the cancer patients.
Five SNPs in the 3' region of the EFNB2 were in linkage disequilibrium and significantly associated with hypertension for male but not female subjects.
These results indicate a novel mechanism of ephrin-Eph signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2(+)extracellular vesicles in neural development and synapse physiology.
Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
miR-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR-137, as a risk factor for schizophrenia
5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src-ERK pathway, and drives EMT via the Src-FAK pathway.
Together, these findings suggest that CCL2, RARRES2 and EFNB2 are host cell factors involved in respiratory syncytial virus replication.
These genes may be potential biomarkers for identification of subclinical lymph node involvement in papillary thyroid carcinoma (PTC)
increased notably in preeclampsia endothelial progenitor cells and placenta
Results suggest a potential signalling hierarchy between Delta-like 1 and ephrin-B2 ligands, as neural stem cells adopt the Delta-like 1 phenotype of stem cell maintenance on simultaneous presentation of both signals.
role in maternal spiral artery remodeling in first trimester
The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
, ephrin-B2 precursor
, ephrin B2
, EPH-related receptor tyrosine kinase ligand 5
, HTK ligand
, eph-related receptor tyrosine kinase ligand 5
, ligand of eph-related kinase 5