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Human Monoclonal EPH Receptor A3 Primary Antibody for RNAi, ELISA - ABIN560754
Peng, Wang, Liu, Ye, Wu, Guo: EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway. in Tumour biology 2016
Human Monoclonal EPH Receptor A3 Primary Antibody for ELISA, WB - ABIN969101
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 2 Pubmed References
Findings suggest that EPH receptor A3 (EphA3) plays an important role in the pathogenesis of multiple myeloma (MM).
Study shows that EphA3 is highly overexpressed in multiple myeloma (MM) and provides evidence that EphA3 plays an important role in MM angiogenesis.
Results indicate that EphA3 protein expression is reduced in clear-cell renal cell carcinoma (显示 MOK 抗体), suggesting the possibility that this receptor functions as a tumor suppressor in this disease.
EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic signaling pathways.
Data indicate that EPHA3 is involved in regulating the multidrug resistance (MDR) of small cell lung cancer (SCLC) via PI3K (显示 PIK3CA 抗体)/BMX (显示 BMX 抗体)/STAT3 (显示 STAT3 抗体) signaling and may be a therapeutic target in SCLC.
PTP-PEST (显示 PTPN12 抗体) regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP (显示 SLC25A3 抗体) controlling EphA3 phosphorylation.
This study showed that EPHA3 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.
A novel association between the EPHA3 deletion and prostate cancer risk was observed in Finnish individuals.
the structure of the ligand-binding domain of the EphA3 receptor in complex with its preferred ligand, ephrin-A5 (显示 EFNA5 抗体), is reported.
EphA3 forms dimers in the absence of ligand binding.
study delineates a mechanism in which NCAM (显示 NCAM1 抗体) promotes ephrin-A5 (显示 EFNA5 抗体)-dependent clustering of EphA3 through interaction of the NCAM (显示 NCAM1 抗体) Ig2 domain and the EphA3 CRD (显示 CRX 抗体), stimulating EphA3 autophosphorylation and RhoA (显示 RHOA 抗体) signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo.
Ephrin-A3 (显示 EFNA3 抗体) has a role in promoting and maintaining slow muscle fiber identity during postnatal development and reinnervation
the physiological role of the putative lung cancer tumor suppressor EPH receptor A3, is reported.
ephrinA5/EphA3 triggers proteolysis of the neural cell adhesion molecule (NCAM (显示 NCAM1 抗体)) by the metalloprotease (显示 ADAMTS7 抗体) a disintegrin and metalloprotease (ADAM)10 (显示 ADAM10 抗体) to promote growth cone collapse in neurons from mouse neocortex.
EphA3 receptor localized only in neuronal cells of the hippocampus was enhanced without transcriptional regulation during synaptic plasticity through activation of the nicotinic acetylcholine receptor.
Data show that a number of Eph (显示 EPHA1 抗体) receptors and ephrins were expressed in hematopoietic stem cells.
Neocortical expression of Epha3 during development remains stable in the absence of cellular contacts and thalamocortical connections.
Retrograde labeling studies in EphA3(-/-) embryos and adults indicate that EphA3 is not necessary to direct motor axons to axial muscle targets.
A discrepancy between mRNA and protein expression was found between early and later developmental stages, suggesting that EphA3 might regulate the formation of various neuronal networks in the developing brain.
results indicate that EphA3 plays a crucial role in the development and morphogenesis of the cells that give rise to the atrioventricular valves and septa (显示 SEPT2 抗体).
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
EPH-like kinase 4
, TYRO4 protein tyrosine kinase
, eph-like tyrosine kinase 1
, ephrin type-A receptor 3
, human embryo kinase 1
, tyrosine-protein kinase receptor ETK1
, ephrin receptor EphA3
, EPH receptor A3
, ephrin type-A receptor 3-like
, tyrosine-protein kinase TYRO4
, tyrosine-protein kinase receptor REK4
, receptor tyrosine kinase
, eph-like receptor tyrosine kinase 7
, tyrosine-protein kinase receptor ZEK1