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Human EPGN Protein expressed in Escherichia coli (E. coli) - ABIN1686210
Tai, Bilousova, Jungbauer, Roeske, Youmans, Yu, Poon, Cornwell, Miller, Vinters, Van Eldik, Fardo, Estus, Bu, Gylys, Ladu: Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. in The Journal of biological chemistry 2013
Study shows how the EGFR (显示 EGFR 蛋白) ligands epiregulin (EREG (显示 EREG 蛋白)) and epigen (EPGN) stabilize different dimeric conformations of the EGFR (显示 EGFR 蛋白) extracellular region. Results reveal how responses to different EGFR (显示 EGFR 蛋白) ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (显示 RET 蛋白) (RTK) signaling specificity.
EPG is an EGF (显示 EGF 蛋白)-like growth factor and a low affinity ligand
activation of the EGFR (显示 EGFR 蛋白) by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density.
Epigen has non-essential functions or functions that can be compensated by other EGFR (显示 EGFR 蛋白) ligands during growth and tissue homeostasis.
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants.
, epithelial mitogen homolog