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Study characterized the functional roles of the two brain-specific phosphorylation sites (S582 and T1067) of CYFIP2 in cultured hippocampal neurons; found that overexpression of the phospho-blocking T1067A mutant significantly decreased the density of stubby spines, but not other types of spines. Study found that T1067 phosphorylation of CYFIP2 could potentially weaken the interaction between CYFIP2 and Nap1.
Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP interactor, is detected in fragile X syndrome.
blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 compared to the levels of expression in control subjects.
Studies identify a novel proapoptotic gene target, CYFIP2, which is downregulated by IMP-1, and mediates the regulation of cell survival and K-Ras expression in colon cancer cells.
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network.
The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter.
cyfip2 is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
Study identified cytoplasmic FMR1-Interacting Protein 2 (Cyfip2) as a major significant genetic factor underlying binge eating and provide a behavioral paradigm for future genome-wide association studies in populations with increased genetic complexity.
Study provides evidence for the role of Cyfip2 in fragile X-like behaviors and regulation of dendritic spines, and for the mGluR-induced regulation of Cyfip2 expression, which could provide new insight into the pathogenesis of the neurological fragile X syndrome phenotypes.
Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity).
cytoplasmic FMR1 interacting protein 2
, cytoplasmic FMR1-interacting protein 2
, p53 inducible protein
, p53-inducible protein 121