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抗Human AATK 抗体:
抗Mouse (Murine) AATK 抗体:
抗Rat (Rattus) AATK 抗体:
ATKK was validated as a target gene of miR (显示 MLXIP 抗体)-558, and upregulation of miR (显示 MLXIP 抗体)-558 was observed in radioresistant lung cancer cells. Additionally, ectopic overexpression of ATKK partially but significantly reduced the miR (显示 MLXIP 抗体)-558-induced radioresistance.
Apoptosis-associated tyrosine kinase is a Cdk5 (显示 CDK5 抗体) activator p35 binding protein.
The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro.
LMTK1 negatively controls dendritic formation by regulating Rab11A (显示 RAB11A 抗体)-positive endosomal trafficking.
Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 (显示 CDK5 抗体) or Src (显示 SRC 抗体)-family kinases
Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase (显示 TYRO3 抗体)-defective mutant significantly inhibited it.
phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
AATYK1 indirectly inhibits the SPAK (显示 STK39 抗体)/WNK4 (显示 WNK4 抗体) activation of the Na-K-2Cl cotransporter (显示 SLC12A1 抗体) by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
, brain apoptosis-associated tyrosine kinase
, lemur tyrosine kinase 1
, p35-binding protein
, serine/threonine-protein kinase LMTK1
, apoptosis-associated tyrosine kinase 1B