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Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity.
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway
Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation.
resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.
MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis.
The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad.
Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation.
Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death.
a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B
differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells.
MAT2B acted as a positive regulator through modifying S- adenosylmethionine levels as well as activating AKT/ERK signaling pathway to promote porcine intramuscular adipocyte differentiation.
These data demonstrated an obesity-related expression variation of the MAT II beta subunit in skeletal muscle and adipose tissue in pigs.
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.
MAT II beta
, beta regulatory subunit of methionine adenosyltransferase
, dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, methionine adenosyltransferase 2 subunit beta
, putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, putative protein product of Nbla02999
, short chain dehydrogenase/reductase family 23E, member 1
, methionine adenosyltransferase 2 beta subunit
, methionine adenosyltransferase II beta
, methionine adenosyltransferase 2beta
, methionine adenosyltransferase II, beta
, methionine adenosyltransferase 2 subunit beta-like