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Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity.
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf (显示 RAF1 蛋白)/MEK (显示 MAP2K1 蛋白)/ERK (显示 EPHB2 蛋白) pathway
resveratrol induces HuR (显示 ELAVL1 蛋白), SIRT1 (显示 SIRT1 蛋白), and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.
MAT2B and GIT1 form a scaffold, which recruits and activates MEK (显示 MAP2K1 蛋白) and ERK (显示 EPHB2 蛋白) to promote growth and tumorigenesis.
The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR (显示 SDPR 蛋白)) core with specificity for the NADP/H cofactor, and harbors the SDR (显示 SDPR 蛋白) catalytic triad.
Coexpression of MAT2A (显示 MAT2A 蛋白) and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR (显示 ELAVL1 蛋白) subcellular content to affect cell proliferation.
Lower expression of both MAT2A (显示 MAT2A 蛋白) and MAT2beta and interfere with leptin (显示 LEP 蛋白) signaling in liver cancer cells.
Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death.
a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B
MAT2B acted as a positive regulator through modifying S- adenosylmethionine levels as well as activating AKT (显示 AKT1 蛋白)/ERK (显示 MAPK1 蛋白) signaling pathway to promote porcine intramuscular adipocyte differentiation.
These data demonstrated an obesity-related expression variation of the MAT II beta subunit (显示 POLG 蛋白) in skeletal muscle and adipose tissue in pigs.
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.
MAT II beta
, beta regulatory subunit of methionine adenosyltransferase
, dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, methionine adenosyltransferase 2 subunit beta
, putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, putative protein product of Nbla02999
, short chain dehydrogenase/reductase family 23E, member 1
, methionine adenosyltransferase 2 beta subunit
, methionine adenosyltransferase II beta
, methionine adenosyltransferase 2beta
, methionine adenosyltransferase II, beta
, methionine adenosyltransferase 2 subunit beta-like