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A genome-wide association study identifies PLCL2 (显示 PLCL2 蛋白) and AP3D1-DOT1L (显示 DOT1L 蛋白)-SF3A2 as new susceptibility loci for myocardial infarction in Japanese
SF3a60 (显示 SF3A3 蛋白), 66, and 120, but not SF1 (显示 NR5A1 蛋白), are essential for pre-mRNA splicing
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.
splicing factor 3A subunit 2
, spliceosome associated protein 62
, splicing factor 3a, subunit 2, 66kDa
, SAP 62
, spliceosomal protein gene 62
, spliceosome-associated protein 62
, splicing factor 3a, subunit 2, 66kD
, pre-mRNA splicing factor SF3A, subunit 2