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HBZ (显示 HBZ 蛋白) induces nuclear retention of RPS25 mRNA in the nucleus and loss of RPS25 protein expression. Inhibition of RPS25 expression stimulates Delta JunD (显示 JUND 蛋白) synthesis.
data demonstrate that ribosomal protein S25 is a novel regulator of the MDM2 (显示 MDM2 蛋白)-p53 (显示 TP53 蛋白) circuit in ribosomal stress; results shed light on biological consequences of RP-MDM2 (显示 MDM2 蛋白)-p53 (显示 TP53 蛋白) interplay and also reveal the existence of a novel S25-p53 (显示 TP53 蛋白) feedback regulatory loop
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
, minute (3) 86D
, minute (3) S32
, ribosomal protein S25
, 40S ribosomal protein S25