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抗Human GEMIN8 抗体:
Human Polyclonal GEMIN8 Primary Antibody for ICC, IF - ABIN4313853
Renvoisé, Quérol, Verrier, Burlet, Lefebvre: A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies. in Journal of cell science 2012
Gemin8 is a novel integral component of the SMN (显示 STMN1 抗体) complex
Gemin8 has an essential role in the proper structural organization of the SMN (显示 STMN1 抗体) complex and the involvement of the heteromeric subunit containing Gemin6 (显示 GEMIN6 抗体), Gemin7 (显示 GEMIN7 抗体), Gemin8, and Unrip (显示 STRAP 抗体) in the recruitment of Sm proteins to the snRNP (显示 LSM2 抗体) assembly pathway
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
family with sequence similarity 51, member A1
, gem-associated protein 8