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Gemin6 is a component of the SMN (显示 STMN1 蛋白) complex that localizes to gems and interacts with several Sm proteins of the spliceosomal snRNPs.
Gemin8 (显示 GEMIN8 蛋白) has an essential role in the proper structural organization of the SMN (显示 STMN1 蛋白) complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7 (显示 GEMIN7 蛋白), Gemin8 (显示 GEMIN8 蛋白), and Unrip (显示 STRAP 蛋白) in the recruitment of Sm proteins to the snRNP (显示 LSM2 蛋白) assembly pathway
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1\; MIM 602595), GEMIN3 (DDX20\; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).
, gem-associated protein 6
, gemin 6