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Human C1QBP Protein expressed in Wheat germ - ABIN1347370
McGee, Baines: Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death. in The Biochemical journal 2010
Human C1QBP Protein expressed in Escherichia coli (E. coli) - ABIN2004865
Jiang, Zhang, Krainer, Xu: Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. in Proceedings of the National Academy of Sciences of the United States of America 1999
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We propose that endogenous gC1qR/p33 physically interacts with MCP-1 (显示 CCL2 蛋白) causing stabilization of the MCP-1 (显示 CCL2 蛋白) protein and stimulation of its activity in human periodontal ligament cells, suggesting a novel gC1qR/p33-mediated pro-inflammatory mechanism of action.
C1QBP may regulate L1CAM (显示 L1CAM 蛋白) expression in renal cell carcinoma (显示 MOK 蛋白) (RCC (显示 XRCC1 蛋白)) through the Wnt (显示 WNT2 蛋白)/beta-Catenin (显示 CTNNB1 蛋白) pathway, thus affecting RCC (显示 XRCC1 蛋白) cell adhesion, migration and metastasis.
Hepatitis C virus core protein ligates gC1qR to induce A20 (显示 TNFAIP3 蛋白) expression in macrophages via P38 (显示 CRK 蛋白), JNK (显示 MAPK8 蛋白) and NF-kappaB (显示 NFKB1 蛋白) signaling pathways, which leads to a low-grade chronic inflammation during HCV infection.
The RAP80 (显示 UIMC1 蛋白) deficiency reduces the protein level of p32 and p32 dependent mitochondrial translating proteins such as Rieske and COX1.
Mutation in C1QBP gene is associated with Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
results implicate p32 as a key host factor for RSV virus production, and bring to light the potential importance of mitochondria in RSV infection
single nucleotide polymorphism srs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women
The authors identified Importin-alpha1 to bind to Coxiella burnetii AnkG and concluded that binding of AnkG to p32 and Importin-alpha1 is essential for its migration into the nucleus.
HABP1 overexpression is associated with cervical cancer.
This study supports a key role for gC1qR in malaria-associated endovascular pathogenesis
Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses, leading to heart failure.
macrophage/neutrophil-specific p32 conditional knockout mice showed exacerbated inflammation and reduced survival in response to LPS. Based on these findings, p32 is an important regulator of inflammatory signaling and is a potential drug candidate for treatment of sepsis in mammals.
application of p33 (显示 LTB 蛋白) significantly improved survival in mice receiving an otherwise lethal dose of histones.
Authors propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria.
we have identified a mitochondrial protein (显示 COX6B2 蛋白) p32 as a novel interactor of parkin (显示 PARK2 蛋白) in the brain
C1qbp could directly bind to CypD. Therefore C1qbp appears to act as an endogenous inhibitor of the MPT pore, most likely through binding to CypD, and thus protects cells against oxidative stress.
Intracellular localization and further functional studies suggested that CHCHD2 and HABP1 may mutually regulate each other to balance cell migration.
Rat and mouse homologs of the HABP1 pseudogene also contain multiple mutations, leading to the insertion of premature stop codons confirming the identity of a processed pseudogene.
Study demonstrates the differential expression of HABP1 during progression of epidermal carcinoma.
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.
p32 subunit of splicing factor SF2
, 38k protein
, complement component 1, q subcomponent binding protein
, ASF/SF2-associated protein p32
, C1q globular domain-binding protein
, complement component 1 Q subcomponent-binding protein, mitochondrial
, glycoprotein gC1qBP
, hyaluronan-binding protein 1
, mitochondrial matrix protein p32
, splicing factor SF2-associated protein
, GC1q-R protein