anti-大鼠 PTF1A 抗体 for Immunohistochemistry (Paraffin-embedded Sections)

PTF1 is a pancreas-specific protein that functions as a component of the trimeric pancreas transcription factor 1 (PTF1) complex. Localizing to the nucleus, PTF1 contains one basic helix-loop-helix (bHLH) domain and is believed to play an important role in mammalian pancreatic development, functioning as a transcription factor that regulates the specification of all three pancreatic cell types. PTF1 interacts with RBP-Jâ...¹ and, together, they cooperate in regulating the expression of PDX-1 (pancreas/duodenum homeobox protein 1), a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. Loss of functional PTF1 can cause pancreatic progenitors to take on the normal fates of duodenal epithelia. Mutations in the gene encoding PTF1 lead to diabetes mellitus and cerebellar hypoplasia/agenesis, suggesting that PTF1 also plays and important role in cerebellar neurogenesis.

Subcellular location: Extracellular

Synonyms: PTF1-p48, bHLH transcription factor p48, bHLHa29, Class A basic helix-loop-helix protein 29, Class II bHLH protein PTF1A, Exocrine pancreas specic transcription factor p48, p48 DNA binding subunit of transcription factor PTF1, p48 DNA-binding subunit of transcription factor PTF1, Pancreas specic transcription factor 1a, Pancreas transcription factor 1 subunit alpha, Pancreas-specic transcription factor 1a, PTF 1A, PTF1 p48, PTF1-p48, Ptf1a, PTF1A_HUMAN, PTF1P48.