This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alternative names and synonyms associated with PITX2
paired like homeodomain 2 (PITX2) ELISA Kit
paired like homeodomain 2 S homeolog (pitx2.S) ELISA Kit
paired like homeodomain 2 (pitx2) ELISA Kit
paired like homeodomain 3 (PITX3) ELISA Kit
paired-like homeodomain 2 (Pitx2) ELISA Kit
paired like homeodomain 2 L homeolog (pitx2.L) ELISA Kit