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抗Mouse (Murine) PRODH 抗体:
抗Human PRODH 抗体:
抗Rat (Rattus) PRODH 抗体:
Human Polyclonal PRODH Primary Antibody for IHC (p), IHC - ABIN251304
Paterlini, Zakharenko, Lai, Qin, Zhang, Mukai, Westphal, Olivier, Sulzer, Pavlidis, Siegelbaum, Karayiorgou, Gogos: Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. in Nature neuroscience 2005
Human Polyclonal PRODH Primary Antibody for ELISA, WB - ABIN4347384
Li, Ma, Hu, Wang, Yan, Meng, Liu, Toulopoulou, Murray, Collier: PRODH gene is associated with executive function in schizophrenic families. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
Human Polyclonal PRODH Primary Antibody for FACS, IHC (p) - ABIN1881685
Polyak, Xia, Zweier, Kinzler, Vogelstein: A model for p53-induced apoptosis. in Nature 1997
knockdown and overexpression of human PRODH and slgA in the lateral neurons ventral (LNv) lead to altered aggressive behavior.
ProDH1 and ProDH2 are both necessary to achieve maximum resistance against Pseudomonas syringae pv. tomato AvrRpm1 and B. cinerea.[ProDH1]
ARR18 interaction negatively interferes with the transcriptional activity of bZIP63 on the PDH1 promoter. [PDH1]
ProDH potentiates the oxidative burst and cell death associated with the hypersensitive response.
ProDH-silenced plants displayed reduced ROS and cell death levels as well as enhanced susceptibility in response to avirulent pathogens.
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth.
Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets
PRODH/POX and succinate regulated mitochondrial respiration.
Proline Dehydrogenase (PRODH) expression is reduced in human with Heart Failure. PRODH appears to be crucial to sustain normal mitochondrial function and maintenance of ATP levels in human cardiomyocytes in a hypoxic environment, as well as for redox homeostasis in both normoxic and hypoxic conditions.
PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells.
this study shows that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of reactive oxygen species
the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 gene in three case-control studies, was studied.
The findings support a major role for the PRODH 757TT, 1766GG, and 1852AA genotypes alone and in combination for schizophrenia susceptibility.
Thirty-five percent of the subjects were hyperprolinemic, allele carriers of PRODH rs450046 had a lower full-scale intelligence compared to T allele carriers
GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15.
results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individuals with VCFS
Functional COMT, but not PRODH, variant affects IQ and executive functions in 22q11.2DS subjects during neurodevelopment with a maximal effect at adulthood
Data indicate that a functional proline dehydrogenase (PRODH) variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder.
The current study demonstrates that sensory gating impairments that are typical of schizophrenia are found in 22q11.2DS subjects. Our results further suggest that COMT and PRODH genetic variations contribute to sensory gating.
PRODH, but not PRODH2, expression is under the control of p53 family members, specifically p53 and p73.
Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH.
distinct molecular alterations of the PRODH gene result in abnormal proline levels.
results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells
There is no association between proline dehydrogenase (oxidase) 1 polymorphisms and schizophrenia in Korean population
The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation, at least partly, via PPARgamma activation.
For a number of genes affected by de novo copy number variants CNVs in autism (CNTNAP2, ZNF214, ARID1B, Proline Dehydrogenase), reduced transcript expression may be a mechanism of pathogenesis during neurodevelopment.
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
proline dehydrogenase (oxidase) 1
, Proline dehydrogenase (Proline oxidase)
, proline dehydrogenase
, proline dehydrogenase, mitochondrial-like
, proline dehydrogenase 1, mitochondrial
, proline dehydrogenase, mitochondrial
, proline oxidase
, p53-induced gene 6 protein
, proline oxidase 2
, proline oxidase, mitochondrial
, tumor protein p53 inducible protein 6
, proline dehydrogenase (proline oxidase)