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Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.
Results indicate that advanced extranodal NK/T cell lymphoma (ENKL) patients with unfavourable treatment outcomes displayed higher levels of S100A9 (显示 S100A9 蛋白) and ORM1.
Glycosylated Alpha-1-acid glycoprotein 1 is ostensibly expressed in lung cancer patients and is a potential lung cancer serum biomarker.
Altogether, these results indicate that alpha1-3 fucosylated glycoforms of AGP are increased in PDAC and could be potentially regarded as a PDAC biomarker.
The results of this study suggest that the expression of VEGF-A (显示 VEGFA 蛋白) and ORM-1 may be associated with two mechanisms (angiogenesis and tumor structural viscosity) that may influence tumor growth in odontogenic myxoma.
Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance
ORM1 stimulates quiescent monocytes to polarize to M2b monocytes.
Identify ORM (显示 ATP5A1 蛋白) genetic variations/haplotype structure associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.
Data indicate that the band intensity of sialic acid content in alpha-1 Acid glycoprotein (AGP) of alcoholic liver cirrhosis was found to be lower than that in pooled control group.
These findings suggest that the ORM (显示 ATP5A1 蛋白) distal promoter region differentially regulates expression of ORM (显示 ATP5A1 蛋白) genes at basal level and in acute phase responses.
This study demonstrated that decreasing the Orm1 expression via inhibition of the NF-kappaB pathway could be a possible mechanism involved in the aggravation of BBB disruption after stroke by VEGF.
alpha(1)-Acid glycoprotein up-regulates CD163 (显示 CD163 蛋白) via TLR4 (显示 TLR4 蛋白)/CD14 protein (显示 ERGIC2 蛋白) pathway: possible protection against hemolysis-induced oxidative stress.
ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction.
alpha-1 acid glycoprotein expression is increased by retinoids at the transcriptional level through two distinct DR1 retinoic acid responsive elements
The presence of lipopolysaccharide binding protein (LBP (显示 LBP 蛋白)) and alpha1-acid glycoprotein (AGP) was demonstrated in all seven adipose tissue depots. Expression of AGP and LBP (显示 LBP 蛋白) suggests that they may have roles as local and systemic inflammatory adipokines.
results provide evidence that locally produced alpha-1 acid glycoprotein may be involved in protecting sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct
Studied the regulation and immune function of AGP in cultured bovine oviduct epithelial cells.
As in human AGP and several other lipocalins, a temperature-induced molten globule state has been observed in the denaturation pathway of bovine AGP.
In the mitochondrial membrane, both AGP and MLQ proteins are almost quantitatively bound to ATP synthase.
study provides evidence that the expression of CD18 (显示 ITGB2 蛋白) was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein and inhibited the chemotaxis of monocytes
data support the consideration that alpha-1 acid glycoprotein is a negative acute-phase reactant and appears to be regulated by cytokines
Data suggest that AGP/ORM1 level in blood at birth is reflective of growth conditions in utero or fetal maturation and may serve as an early predictive biomarker for pre-weaning growth rate.
Data indicate decreases in serum alpha-1 acid glycoprotein concentration and in hepatic ORM1 expression during the acute phase response.
expression of ORM1 mRNA in liver, adipose tissue well as the serum concentration of ORM protein in three porcine obesity models; the domestic pig, Gottingen minipigs and Ossabaw minipigs
This study suggested closer links between the release of haptoglobin (显示 HP 蛋白), Pig-MAP and monocytes compared to the release of AGP, SAA (显示 SAA1 蛋白) and transthyretin (显示 TTR 蛋白).
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined\; however, it may be involved in aspects of immunosuppression.
, AGP 1
, OMD 1
, alpha-1-acid glycoprotein 1
, alpha-1-acid glycoprotein-2
, bM340H1.2 (orosomucoid 1)
, acute phase protein
, alpha-1 acid glycoprotein
, alpha 1-acid glycoprotein