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Human s100b Protein expressed in Escherichia coli (E. coli) - ABIN1097989
Cerofolini, Amato, Borsi, Pagano, Randazzo, Fragai: Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands. in Journal of molecular recognition : JMR 2015
It is unclear if the higher S100B concentration in football players playing at least 50 plays was caused by exercise or impacts. Therefore, if serum S100B is to be used as a biomarker of impacts, and possible brain injury in sport, exercise time and intensity should be taken into account as confounding variables.
High S100B expression is associated with chemoresistance in ovarian cancer.
The serum levels of S100B in Groups A and B rose after the injury and reached a peak on the 4th day of injury. Serum levels of NSE (显示 ENO2 蛋白) and S100B protein can reflect the degree of spinal cord injury.
Serum levels of S100B (and neuron-specific enolase (显示 ENO2 蛋白)) at admission were related to initial Glasgow Coma Scale (GSC (显示 GSC 蛋白)) scores, and these levels one week after traumatic brain injury were related to six month GSC (显示 GSC 蛋白) scores.
Studied use of serum S100B as a biomarker to predict injury in patients with mild head injury. Found patients with cranial injury detected by CT, had higher S100B protein levels than those without cranial injury.
A high S100B expression is associated with a good prognosis in patients with p53 (显示 TP53 蛋白) mutant and p53 (显示 TP53 蛋白) wild-type breast cancers.
S100B may have a role in pathogenesis of schizophrenia; patients show higher plasma levels of S100B than healthy controls
We investigated the possible correlation between TCD results and S100B, NSE and LDH levels as well as between NSE-LDH and S100B-LDH levels by regression analysis. We found a statistically significant relationship for both NSE, S100B with LDH.
Results showed that our prepared S100B mAbs were suitable for detecting S100B expression in human tissues, furnishing promising tools for further functional investigation and clinical applications.
In this study demonstrated that S100b is elevated in Alzheimer disease cases. and the increased levels in African Americans here may be indicative of increased severity in specific populations.
Data (including data from studies in knockout mice) suggest that S100b acting as a humoral factor impairs glycolysis in muscle (myoblasts, myotubes, and skeletal muscles) independent of insulin (显示 INS 蛋白) action; this effect appears to be due to inhibition of Gapdh (显示 GAPDH 蛋白) activity from enhanced poly(ADP-ribosyl)ation of Gapdh (显示 GAPDH 蛋白). (S100B = S100 protein, beta polypeptide (显示 MS4A2 蛋白), neural; Gapdh (显示 GAPDH 蛋白) = glyceraldehyde-3-phosphate dehydrogenase (显示 GAPDH 蛋白))
S100B inhibits C3H/10T1/2 murine embryonic mesenchyma.l cells into osteoblasts. S100B stimulates C3H/10T1/2 cell differentiation into adipocytes.
The results of this study showed that S100B affects behavioral despair in female mice through functional interaction with the 5-HT7 receptor.
Data show that S100B has direct effects on macrophages, enhancing particularly CCL22 (显示 CCL22 蛋白) and IL-1beta (显示 IL1B 蛋白) expression and modulates the inflammatory response in uveoretinitis and this is likely to be, at least in part, via a direct effect on macrophages.
Data show that high glucose increased protein-protein interaction between Steap4 (显示 STEAP4 蛋白) and S100B in mesangial (MES13) cells.
high glucoseinduced profibrotic genes (TGFbeta (显示 TGFB1 蛋白), type IV collagen (显示 COL4 蛋白) and fibronectin (显示 FN1 蛋白)) and cell hypertrophyrelated p21WAF1 are dependent on S100B.
S100A1 (显示 S100A1 蛋白) and S100B are dispensable for endochondral ossification during skeletal development.
Data suggest up-regulation of S100b/RAGE (显示 AGER 蛋白) (advanced glycosylation end-product receptor) signaling plays role in inflammatory interaction between adipocytes/macrophages; adipocyte secretion of S100b is up-regulated by Tnf (tumor necrosis factor-alpha (显示 TNF 蛋白)).
Gioma production of S100B enhancestumor growth through CCL2 (显示 CCL2 蛋白) upregulation and tumor-associated macrophages chemoattraction.
HMGB1 (显示 HMGB1 蛋白), S100B, and RAGE (显示 AGER 蛋白) signaling modulate the hippocampal inflammatory response and might play key roles in surgery-induced cognitive decline.
As CSF (显示 CSF2 蛋白)-S100B levels in calves with neurologic diseases widely differed, the utility of CSF (显示 CSF2 蛋白)-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.
S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE (显示 AGER 蛋白)-dependent regulation of several inflammation-related events including activation and migration of microglia
X-ray crystallography was used here to characterize an interaction between Ca(2 (显示 CA2 蛋白))(+)-S100B and TRTK-12, a target that binds to the p53 (显示 TP53 蛋白)-binding site on S100B.
Intracellular S100B might modulate myoblast differentiation by interfering with MyoD (显示 MYOD1 蛋白) expression in an NF-kappaB (显示 NFKB1 蛋白)-dependent manner.
S100b activates guanylate cyclase in a calcium-dependent manner [review]
Structural studies in combination with biochemical data are used to develop a model for calcium-induced activation of human nuclear serine/threonine kinase (NDR (显示 STK38 蛋白)) kinase by S100B.
S100B shows a sufficient thermostability to resist pasteurization but not spry-drying in milk formulas for preterm and term infants.
Structures of pentamidine (Pnt (显示 ETS2 蛋白)) bound to Ca(2 (显示 CA2 蛋白)+)-loaded and Zn(2+),Ca(2 (显示 CA2 蛋白)+)-loaded S100B were determined by X-ray crystallography at 2.15 A (R(free)=0.266) and 1.85 A (R(free)=0.243) resolution, respectively.
The time course of S100B serum values following spinal cord decompression correlates with outcome; the initial degree of paresis is not a prognostic factor to predict outcome.
This study demonstrated that One singular glomerulus (mdG2) exhibits S100 and parvalbumin (显示 PVALB 蛋白)-positive fibers, apparently originating from all crypt cells plus some microvillous olfactory sensory neuronss.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21\; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
S-100 calcium-binding protein, beta chain
, S-100 protein subunit beta
, S100 calcium-binding protein, beta (neural)
, protein S100-B
, S-100 protein beta chain
, S100 calcium-binding protein B
, S100 calcium-binding protein beta (neural)
, S100 protein, beta polypeptide, neural
, S100 protein, beta polypeptide
, S100 calcium binding protein, beta (neural)
, S100 calcium-binding protein, beta
, S-100 calcium-binding protein beta subunit