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Human s100b Protein expressed in Escherichia coli (E. coli) - ABIN1097989
Cerofolini, Amato, Borsi, Pagano, Randazzo, Fragai: Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands. in Journal of molecular recognition : JMR 2015
Results showed that our prepared S100B mAbs were suitable for detecting S100B expression in human tissues, furnishing promising tools for further functional investigation and clinical applications.
In this study demonstrated that S100b is elevated in Alzheimer disease cases. and the increased levels in African Americans here may be indicative of increased severity in specific populations.
In neonates, NSE (显示 ENO2 蛋白) and s100B levels increase after bypass surgery and return below preoperative baseline levels by postoperative day seven. The levels of s100B were positively correlated with circulatory arrest time and negatively correlated with age at time of surgery.
found that S100B plays a crucial role in blocking the interaction site between RAGE (显示 AGER 蛋白) V domain and S100A1 (显示 S100A1 蛋白). A cell proliferation assay WST (显示 EEF1A2 蛋白)-1 also supported our results. This report could potentially be useful for new protein development for cancer treatment
the serum levels of S100B protein mediated the association between S100B gene polymorphism and scene selectivity in the retrosplenial cortex
There is a significant correlation between mortality in the critically ill patients in the intensive care unit and increased serum concentration of S100B and NSE (显示 ENO2 蛋白).
Our findings showed that both S100beta and NSE (显示 ENO2 蛋白) levels similarly increased during CPB (显示 CPB1 蛋白) and immediately after CPB (显示 CPB1 蛋白) during sevoflurane and propofol based anesthesia.
This study demonstrated that S100A12 (显示 S100A12 蛋白) mRNA levels were significantly decreased in the new cases of untreated MS patients in comparison to healthy controls.
Increased serum levels of S100B protein (and NSE (显示 ENO2 蛋白)) were observed postoperatively in patients with postoperative cognitive dysfunction.
high S100B expression in Multiple Sclerosis (MS) patient samples suggests its usefulness as a diagnostic biomarker for MS.
Data (including data from studies in knockout mice) suggest that S100b acting as a humoral factor impairs glycolysis in muscle (myoblasts, myotubes, and skeletal muscles) independent of insulin (显示 INS 蛋白) action; this effect appears to be due to inhibition of Gapdh (显示 GAPDH 蛋白) activity from enhanced poly(ADP-ribosyl)ation of Gapdh (显示 GAPDH 蛋白). (S100B = S100 protein, beta polypeptide (显示 MS4A2 蛋白), neural; Gapdh (显示 GAPDH 蛋白) = glyceraldehyde-3-phosphate dehydrogenase (显示 GAPDH 蛋白))
S100B inhibits C3H/10T1/2 murine embryonic mesenchyma.l cells into osteoblasts. S100B stimulates C3H/10T1/2 cell differentiation into adipocytes.
The results of this study showed that S100B affects behavioral despair in female mice through functional interaction with the 5-HT7 receptor.
Data show that S100B has direct effects on macrophages, enhancing particularly CCL22 (显示 CCL22 蛋白) and IL-1beta (显示 IL1B 蛋白) expression and modulates the inflammatory response in uveoretinitis and this is likely to be, at least in part, via a direct effect on macrophages.
Data show that high glucose increased protein-protein interaction between Steap4 (显示 STEAP4 蛋白) and S100B in mesangial (MES13) cells.
high glucoseinduced profibrotic genes (TGFbeta (显示 TGFB1 蛋白), type IV collagen (显示 COL4 蛋白) and fibronectin (显示 FN1 蛋白)) and cell hypertrophyrelated p21WAF1 are dependent on S100B.
S100A1 (显示 S100A1 蛋白) and S100B are dispensable for endochondral ossification during skeletal development.
Data suggest up-regulation of S100b/RAGE (显示 AGER 蛋白) (advanced glycosylation end-product receptor) signaling plays role in inflammatory interaction between adipocytes/macrophages; adipocyte secretion of S100b is up-regulated by Tnf (tumor necrosis factor-alpha (显示 TNF 蛋白)).
Gioma production of S100B enhancestumor growth through CCL2 (显示 CCL2 蛋白) upregulation and tumor-associated macrophages chemoattraction.
HMGB1 (显示 HMGB1 蛋白), S100B, and RAGE (显示 AGER 蛋白) signaling modulate the hippocampal inflammatory response and might play key roles in surgery-induced cognitive decline.
As CSF (显示 CSF2 蛋白)-S100B levels in calves with neurologic diseases widely differed, the utility of CSF (显示 CSF2 蛋白)-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.
S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE (显示 AGER 蛋白)-dependent regulation of several inflammation-related events including activation and migration of microglia
X-ray crystallography was used here to characterize an interaction between Ca(2 (显示 CA2 蛋白))(+)-S100B and TRTK-12, a target that binds to the p53 (显示 TP53 蛋白)-binding site on S100B.
Intracellular S100B might modulate myoblast differentiation by interfering with MyoD (显示 MYOD1 蛋白) expression in an NF-kappaB (显示 NFKB1 蛋白)-dependent manner.
S100b activates guanylate cyclase in a calcium-dependent manner [review]
Structural studies in combination with biochemical data are used to develop a model for calcium-induced activation of human nuclear serine/threonine kinase (NDR (显示 STK38 蛋白)) kinase by S100B.
S100B shows a sufficient thermostability to resist pasteurization but not spry-drying in milk formulas for preterm and term infants.
Structures of pentamidine (Pnt (显示 ETS2 蛋白)) bound to Ca(2 (显示 CA2 蛋白)+)-loaded and Zn(2+),Ca(2 (显示 CA2 蛋白)+)-loaded S100B were determined by X-ray crystallography at 2.15 A (R(free)=0.266) and 1.85 A (R(free)=0.243) resolution, respectively.
The time course of S100B serum values following spinal cord decompression correlates with outcome; the initial degree of paresis is not a prognostic factor to predict outcome.
This study demonstrated that One singular glomerulus (mdG2) exhibits S100 and parvalbumin (显示 PVALB 蛋白)-positive fibers, apparently originating from all crypt cells plus some microvillous olfactory sensory neuronss.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21\; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
S-100 calcium-binding protein, beta chain
, S-100 protein subunit beta
, S100 calcium-binding protein, beta (neural)
, protein S100-B
, S-100 protein beta chain
, S100 calcium-binding protein B
, S100 calcium-binding protein beta (neural)
, S100 protein, beta polypeptide, neural
, S100 protein, beta polypeptide
, S100 calcium binding protein, beta (neural)
, S100 calcium-binding protein, beta
, S-100 calcium-binding protein beta subunit