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抗Human PTBP1 抗体:
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抗Rat (Rattus) PTBP1 抗体:
Human Polyclonal PTBP1 Primary Antibody for WB - ABIN1881702
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
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Human Polyclonal PTBP1 Primary Antibody for IHC (p), IHC - ABIN250017
Cote, Zhu, Thomas, Martin, Murad, Sharina: Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. in PLoS ONE 2012
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Cow (Bovine) Polyclonal PTBP1 Primary Antibody for WB - ABIN2778815
Somberg, Zhao, Fröhlich, Evander, Schwartz: Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632. in Journal of virology 2008
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inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.
Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon
PTBP1 is a novel regulator of MCL1 (显示 MCL1 抗体) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB interacts specifically with 3'UTR (显示 UTS2R 抗体) of p53 (显示 TP53 抗体) mRNA and positively regulates expression of p53 (显示 TP53 抗体) isoforms. PTB showed some overlapping binding regions in the p53 (显示 TP53 抗体) 3'UTR (显示 UTS2R 抗体) with miR (显示 MLXIP 抗体)-1285. Knockdown of miR (显示 MLXIP 抗体)-1285 as well as expression of p53 (显示 TP53 抗体) 3'UTR (显示 UTS2R 抗体) with mutated miR (显示 MLXIP 抗体)-1285 binding sites resulted in enhanced association of PTB with the 3'UTR (显示 UTS2R 抗体), which provides mechanistic insights of this interplay.
It has been established that PTBP1 and PTBP2 (显示 PTBP2 抗体) are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (显示 RNPC3 抗体) complexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.
Studied interactions of polypyrimidine tract-binding protein (PTBP1), pyruvate kinase M2 (PKM2), and STAT3 (signal transducer and activator of transcription 3 (显示 STAT3 抗体)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 is crucial for PKM2 phosphorylation of STAT3 (显示 STAT3 抗体) in the nucleus.
Expression of ATG10 (显示 ATG10 抗体) negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (显示 SLU7 抗体) PTBP1 revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
CD5 (显示 CD5 抗体) transcription is increased, leading to the production of three mRNA isoforms by APA (显示 ENPEP 抗体), all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1 (显示 PAGR1 抗体), leading to an increase in mRNA levels and miR (显示 MLXIP 抗体)-204 targets the longer CD5 (显示 CD5 抗体) mRNA.
Increased expression of microRNA miR (显示 MLXIP 抗体)-145 combined with knockdown of PTBP1 protein contributed to the greater and longer growth suppression compared with each single treatment.
In round spermatids, MRG15 (显示 MORF4L1 抗体) colocalizes with splicing factors PTBP1 and PTBP2 (显示 PTBP2 抗体) at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2 (显示 TNP2 抗体)). Thus, our results reveal that MRG15 (显示 MORF4L1 抗体) is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
This knockin Ptbp1 rescued a forebrain-specific, but not a pan (显示 SUPT6H 抗体)-neuronal, Ptbp2 (显示 PTBP2 抗体) knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 and PTBP2 (显示 PTBP2 抗体).
Results indicate that heterogeneous nuclear ribonucleoprotein I (hnRNPI) plays a critical role in establishing neonatal immune adaptation and preventing colitis and colorectal cancer.
Thus, PTBP1 controls the activity of Pbx1 (显示 PBX1 抗体) to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha (显示 CAMK2 抗体) transcripts in the lens
This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.
The expression levels of three splicing factors, ESRP1 (显示 ESRP1 抗体), PTB and SF2/ASF (显示 SRSF1 抗体), are significantly altered during cardiac hypertrophy in mice.
Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (显示 MLXIP 抗体)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
The polypyrimidine tract binding proteins PTBP1 and PTBP2 (显示 PTBP2 抗体) repressed Psd-95 (显示 DLG4 抗体) (also known as Dlg4 (显示 DLG4 抗体)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.
Data report on a zebrafish maternal-effect (显示 NLRP5 抗体) mutant, brom bones, which is defective in the cytosolic Ca(2 (显示 CA2 抗体)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity
PTB1 is a splicing factor (显示 SLU7 抗体) that influences alternative splicing and acts at the polypyrimidine tract.
Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.
AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, polypyrimidine tract-binding protein 1
, polypyrimidine tract binding protein 1
, hnrnp I
, hnRNP I-related RNA transport protein VgRBP60
, polypyrimidine tract-binding protein
, pyrimidine binding protein 1
, pyrimidine binding protein 2
, brom bones
, LOW QUALITY PROTEIN: polypyrimidine tract-binding protein 1