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Chicken Monoclonal ILK Primary Antibody for IF, WB - ABIN968662
Delcommenne, Tan, Gray, Rue, Woodgett, Dedhar: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. in Proceedings of the National Academy of Sciences of the United States of America 1998
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Chicken Monoclonal ILK Primary Antibody for IF, WB - ABIN968661
Hannigan, Leung-Hagesteijn, Fitz-Gibbon, Coppolino, Radeva, Filmus, Bell, Dedhar: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. in Nature 1996
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Human Monoclonal ILK Primary Antibody for FACS, IHC - ABIN1098122
Taylor, Qiao, Colon, Schlegel, Josifi, Chung: Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells. in Surgery 2011
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Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391993
Troussard, Mawji, Ong, Mui, St -Arnaud, Dedhar: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. in The Journal of biological chemistry 2003
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Human Polyclonal ILK Primary Antibody for IHC, ELISA - ABIN1585644
Porcheri, Suter, Jessberger: Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Human Polyclonal ILK Primary Antibody for IHC, WB - ABIN223143
Hu, Sun, Xie, Huang, Jia, Yao, Ge: Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. in Journal of cardiovascular pharmacology and therapeutics 2013
Human Polyclonal ILK Primary Antibody for ICC, IF - ABIN253069
Dejaeger, Böhm, Dirckx, Devriese, Nefyodova, Cardoen, St-Arnaud, Tournoy, Luyten, Maes: Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017
Human Polyclonal ILK Primary Antibody for DB - ABIN650820
Srikanth, Das, Berns, Kim, Stupp, Kessler: Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. in Neuro-oncology 2013
Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (显示 LIMS1 抗体), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
PINCH (显示 LIMS1 抗体) and ILK have an independent capacity to localize at muscle attachment sites in vivo.
ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (显示 POSTN 抗体) activation of signaling pathways involved in cyst growth and fibrosis in PKD (显示 PRKD1 抗体).
Ilk and ELMO2 (显示 ELMO2 抗体) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin (显示 CDH1 抗体)-based adherens junctions.
Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices.
It was concluded that ILK depletion modifies the transcription of GLUT4 (显示 SLC2A4 抗体), which results in reduced peripheral insulin (显示 INS 抗体) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (显示 INS 抗体) resistance.
results demonstrate that TGF-beta1 (显示 TGFB1 抗体)-induced autophagy links beta-catenin (显示 CTNNB1 抗体) and Smad (显示 SMAD1 抗体) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 抗体)/p-Smad2 (显示 SMAD2 抗体)/ILK pathway.
ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.
Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.
iNOS (显示 NOS2 抗体)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.
Hepatic ILK deletion has no effect on insulin (显示 INS 抗体) action in lean mice but sensitizes the liver to insulin (显示 INS 抗体) during the challenge of high fat feeding. This effect corresponds to changes in the expression and activation of key insulin (显示 INS 抗体) signaling pathways as well as a greater capacity for hepatic mitochondrial glucose oxidation.
this study has identified a new role for Parvin (显示 PARVA 抗体) and alphaPix (显示 ARHGEF6 抗体) downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.
Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.
The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.
Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.
Herein, we propose a new ILK-MMP9 (显示 MMP9 抗体)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment
The current data support MT1-MMP (显示 MMP14 抗体) as an additional ILK substrate and show that modulation of ILK expression and activity inhibit MT1-MMP (显示 MMP14 抗体)-related pro-metastatic behaviors of ovarian cancer cells.
Results show that ILK is overexpressed in metastasis of bladder cancer and the up-regulation of ILK could increase cell proliferation, change cell morphology and regulate cell cycle promoting epithelial-mesenchymal transition.
This study is the first to identify EMILIN-1 (显示 EMILIN1 抗体) and ILK as prospective markers of islet regenerative function in human mesenchymal stem cells.
ILK aids trophoblast syncytialization via downregulation of CDH1 (显示 CDH1 抗体), perhaps through an ILK-PARP1 (显示 PARP1 抗体)-SNAI1 (显示 SNAI1 抗体) pathway
Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by by facilitating the mesenchymal-epithelial transition through targeting integrin-linked kinase.
KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes.
Data indicate a regulatory role for tetraspanin 8 (Tspan8 (显示 TSPAN8 抗体)) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 (显示 TSPAN8 抗体) as a negative regulator of ILK activity.
Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Profilin (显示 PFN1 抗体)-dependent dissociation of G-actin (显示 ACTB 抗体)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, Integrin-linked kinase
, integrin linked kinase
, integrin-linked protein kinase
, integrin-linked kinase
, Integrin-linked protein kinase
, integrin binding protein kinase
, main squeeze
, beta-integrin-linked kinase
, 59 kDa serine/threonine-protein kinase
, integrin-linked kinase-2