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Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 (显示 NETO2 ELISA试剂盒) on the desensitization properties of GluK1 (显示 GRIK1 ELISA试剂盒) homomeric receptors
Neto1 is concluded to be a component of amyloid precursor protein (显示 APP ELISA试剂盒) /NMDA receptor trafficking complexes
no evidence for the association of NETO1 with schizophrenia in the Japanese population
Mouse neto1 plays a critical role in spatial learning and memory through the regulation of NMDAR subunit abundance at synapses.
These results confirm that Neto protein interactions regulate synaptic localization of NMDA and kainate receptor subunits at mossy fiber-CA3 (显示 CA3 ELISA试剂盒) pyramidal cell synapses.
This study demonistrated that Neto1 to regulate both NMDARs and KARs (显示 KARS ELISA试剂盒) reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate (显示 GRIN1 ELISA试剂盒) receptors in a synapse-specific fashion.
The results of this study indicated that two distinctive properties of native kainate receptors, their high-affinity binding pattern in the brain and slow kinetics at postsynapses, are conferred by the kainate receptors auxiliary subunit Neto1.
Assembly with NETO1 and NETO2 (显示 NETO2 ELISA试剂盒) differentially modifies homomeric glutamate (显示 GRIN1 ELISA试剂盒) K1 (GluK1 (显示 GRIK1 ELISA试剂盒)) kainate receptor gating.
Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific (显示 CALY ELISA试剂盒) transmembrane protein containing two CUB and an LDLa (显示 LDLR ELISA试剂盒) domains), which has significant homology with neuropilin-1 (显示 NRP1 ELISA试剂盒) and -2 in their CUB domains. [Btcl1]
Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition.
Focuses mainly on human NETO1 but also describes identification of mouse Neto1.
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
, neuropilin and tolloid-like protein 1