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抗Human NETO1 抗体:
抗Mouse (Murine) NETO1 抗体:
抗Rat (Rattus) NETO1 抗体:
Human Polyclonal NETO1 Primary Antibody for ELISA, WB - ABIN1030539
Lindstrom, Ryan, Shi, DeVries: Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. in The Journal of physiology 2014
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 (显示 NETO2 抗体) on the desensitization properties of GluK1 (显示 GRIK1 抗体) homomeric receptors
Neto1 is concluded to be a component of amyloid precursor protein (显示 APP 抗体) /NMDA receptor trafficking complexes
no evidence for the association of NETO1 with schizophrenia in the Japanese population
Mouse neto1 plays a critical role in spatial learning and memory through the regulation of NMDAR subunit abundance at synapses.
The data of this study showed that a novel role for NETO1 in regulation of axonal Kainate Receptors and identify its physiological significance in development of the CA3 (显示 CA3 抗体)-CA1 (显示 CA1 抗体) circuit.
KAR (显示 HSD17B12 抗体)-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 (显示 NETO2 抗体) knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts.
GluK2 (显示 GRIK2 抗体) surface and synaptic expression are independent on the auxiliary subunits Neto1 and Neto2 (显示 NETO2 抗体). In the CA1 (显示 CA1 抗体) hippocampal pyramidal cell, GluK2 (显示 GRIK2 抗体), in contrast to GluK1 (显示 GRIK1 抗体), traffics to the neuronal surface and synapse efficiently and the auxiliary subunits rNeto1 and mNeto2 caused no further enhancement of these 2 trafficking processes.
These results confirm that Neto protein interactions regulate synaptic localization of NMDA and kainate receptor subunits at mossy fiber-CA3 (显示 CA3 抗体) pyramidal cell synapses.
This study demonistrated that Neto1 to regulate both NMDARs and KARs (显示 KARS 抗体) reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate (显示 GRIN1 抗体) receptors in a synapse-specific fashion.
The results of this study indicated that two distinctive properties of native kainate receptors, their high-affinity binding pattern in the brain and slow kinetics at postsynapses, are conferred by the kainate receptors auxiliary subunit Neto1.
Assembly with NETO1 and NETO2 (显示 NETO2 抗体) differentially modifies homomeric glutamate (显示 GRIN1 抗体) K1 (GluK1 (显示 GRIK1 抗体)) kainate receptor gating.
Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific (显示 CALY 抗体) transmembrane protein containing two CUB and an LDLa (显示 LDLR 抗体) domains), which has significant homology with neuropilin-1 (显示 NRP1 抗体) and -2 in their CUB domains. [Btcl1]
Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition.
Focuses mainly on human NETO1 but also describes identification of mouse Neto1.
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
, neuropilin and tolloid-like protein 1