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抗Human NETO1 抗体:
抗Mouse (Murine) NETO1 抗体:
抗Rat (Rattus) NETO1 抗体:
Human Polyclonal NETO1 Primary Antibody for ELISA, WB - ABIN1030539
Lindstrom, Ryan, Shi, DeVries: Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. in The Journal of physiology 2014
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors
Neto1 is concluded to be a component of amyloid precursor protein /NMDA receptor trafficking complexes
no evidence for the association of NETO1 with schizophrenia in the Japanese population
Mouse neto1 plays a critical role in spatial learning and memory through the regulation of NMDAR subunit abundance at synapses.
The data of this study showed that a novel role for NETO1 in regulation of axonal Kainate Receptors and identify its physiological significance in development of the CA3-CA1 circuit.
KAR-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts.
GluK2 surface and synaptic expression are independent on the auxiliary subunits Neto1 and Neto2. In the CA1 hippocampal pyramidal cell, GluK2, in contrast to GluK1, traffics to the neuronal surface and synapse efficiently and the auxiliary subunits rNeto1 and mNeto2 caused no further enhancement of these 2 trafficking processes.
These results establish critical roles for Neto auxiliary subunits controlling Kainate receptor properties and synaptic incorporation.
These results confirm that Neto protein interactions regulate synaptic localization of NMDA and kainate receptor subunits at mossy fiber-CA3 pyramidal cell synapses.
This study demonistrated that Neto1 to regulate both NMDARs and KARs reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion.
The results of this study indicated that two distinctive properties of native kainate receptors, their high-affinity binding pattern in the brain and slow kinetics at postsynapses, are conferred by the kainate receptors auxiliary subunit Neto1.
Assembly with NETO1 and NETO2 differentially modifies homomeric glutamate K1 (GluK1) kainate receptor gating.
Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific transmembrane protein containing two CUB and an LDLa domains), which has significant homology with neuropilin-1 and -2 in their CUB domains. [Btcl1]
Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition.
Focuses mainly on human NETO1 but also describes identification of mouse Neto1.
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
, neuropilin and tolloid-like protein 1