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NTRC plays a pivotal role in chloroplast redox regulation, being necessary for the activity of diverse thioredoxins with unrelated functions.
NTRC-mediated regulation of the Calvin-Benson cycle and ATP synthesis occurs both directly and through interaction with the ferredoxin-thioredoxin (显示 TXN 蛋白) system and is crucial when availability of light is limiting photosynthesis.
NTRC is highly sensitive to rapidly changing light intensities.NTRC is not responsible for 'metabolism-related' regulation of the ATP synthase.
cooperative control of chloroplast functions via the FTR/Trx (显示 TXN 蛋白) and NTRC pathways is essential for plant viability
These data uncover a new role for NTRC in the control of photosynthetic yield.
An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx (显示 SRX1 蛋白) shows a phenotype similar to the ntrc mutant, while the srx (显示 SRX1 蛋白) mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys (显示 DNAJC5 蛋白) peroxiredoxins.
NADPH thioredoxin reductase C is involved in redox regulation of the Mg-chelatase I subunit in Arabidopsis thaliana chloroplasts
interaction of chloroplast 2-Cys (显示 DNAJC5 蛋白) peroxiredoxin with NADPH (显示 NQO1 蛋白)-thioredoxin reductase C (NTRC) and thioredoxin (显示 TXN 蛋白) x
The strongest reduction in ntrc growth occurred under photoperiods with nights longer than 14 h, whereas knockout of the NTRC gene did not alter the circadian-clock-controlled growth. Lack of NTRC modulated chloroplast reactive oxygen species metabolism.
heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH
Selenoprotein TRXR-1 and GSR-1 (显示 GSR 蛋白) are essential for removal of old cuticle during molting in Caenorhabditis elegans.
In human colonic epithelial cells, significant upregulation of NAD(P)H dehydrogenase (显示 NQO1 蛋白) [quinone] 1 (up to threefold) and thioredoxin reductase 1 (up to twofold) by 10muM sulforaphane (from broccoli), 5muM carnosol (rosemary), and 20muM cinnamaldehyde (cinnamon) was observed.
The reducing system of PTEN was comprised of NADPH (显示 NQO1 蛋白), thioredoxin reductase (TrxR1 (显示 GSR 蛋白)), and thioredoxin (Trx (显示 TXN 蛋白)).
These results suggest that TrxR1 suppresses anabolic metabolism and adipogenesis by inhibition of intracellular signaling pathways downstream of insulin (显示 INS 蛋白) stimulation.
However, Ethaselen can induce a high level of ROS (显示 ROS1 蛋白) in K562/CDDP by TrxR activity inhibition and increased ratio of Bax (显示 BAX 蛋白) to Bcl-2 (显示 BCL2 蛋白) in K562/CDDP by nuclear factor kappaB (NF-kappaB (显示 NFKB1 蛋白)) suppression, which subsequently induces the release of cytochrome c (显示 CYCS 蛋白) in K562/CDDP. This response is partly responsible for the reversal of the cisplatin resistance in K562/CDDP cells.
Multivariate analysis found TXNRD1 was an independent prognostic factor for hepatocellular carcinoma (HCC (显示 FAM126A 蛋白))patients. In conclusion, our data suggested that TXNRD1 was a biomarker for the prognosis of patients with HCC (显示 FAM126A 蛋白).
Mechanistic study uncovers for the first time that the selenoprotein thioredoxin reductase (TrxR) is one of the targets by which PL-CL promotes the ROS generation
Endogenous TrxR1 is sensitive to nitrosylation-dependent inactivation.
This study thus provides novel insights into the catalytic mechanisms of TrxR1. One-electron juglone reduction by TrxR1 producing superoxide should furthermore contribute to the well-known prooxidant cytotoxicity of juglone
Mutation of TXNRD1 was identified in a family with genetic generalized epilepsy.
Data show that small molecule B19 targets and inactivates thioredoxin reductase 1 (TrxR1) in gastric cancer cells.
The developmental expression of cytosolic glutathione peroxidase (显示 GPX1 蛋白) and TRXR1 during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
regenerated coronary endothelial cells exhibit downregulation of thioredoxin reductase
These results suggest that thioredoxin reductase (显示 PRDX5 蛋白) may act as a positive regulator of NF-kappa B (显示 NFKB1 蛋白) and may play an important role in the cellular inflammatory response.
data provide evidence for the involvement of the Trx/TrxR (显示 GSR 蛋白) system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
GSR (显示 GSR 蛋白) is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin (显示 TXN 蛋白) reductase (显示 PRDX2 蛋白) system can probably operate as a functional backup for GSR (显示 GSR 蛋白).
TrxR1 represents a novel therapeutic target to prevent oxygen-mediated neonatal lung injury through Nrf2 (显示 NFE2L2 蛋白).
The results demonstrate that DATS protects against oxidative stress-induced (显示 SQSTM1 蛋白) DNA damage and apoptosis in C2C12 cells in part through the activation of Nrf2 (显示 NFE2L2 蛋白)-mediated TrxR1 induction via the ERK (显示 EPHB2 蛋白) signaling pathway.
Collectively, our results suggest that MsrA (显示 MSR1 蛋白) protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression.
the timely upregulation of Trx1 (显示 TXN 蛋白)/TrxR1 and the active control of intracellular redox status is critical for the survival of thymocytes during and short after positive selection.
Considering the variable expression levels of Sep15 (显示 SEP15 蛋白) and TR1 found within the human population, our results provide insights into new roles of selenoproteins in cancer
Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.
Augmentation of GSH systems by TrxR1 inhibition could represent a promising therapeutic approach to attenuate oxidant-mediated lung injury and improve patient outcomes.
Because the N-terminal domain of Sepp1 (显示 SEPP1 蛋白) has a thioredoxin (显示 TXN 蛋白) fold, Sepp1 (显示 SEPP1 蛋白)(UF) were compared with full-length Sepp1 (显示 SEPP1 蛋白), Sepp1 (显示 SEPP1 蛋白)(Delta240-361), and Sepp1 (显示 SEPP1 蛋白)(U40S) as a substrate of thioredoxin reductase-1 (TrxR1).
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
thioredoxin reductase 1, cytoplasmic
, thioredoxin reductase 3
, thioredoxin reductase 1
, thioredoxin reductase 1, cytoplasmic-like
, KM-102-derived reductase-like factor
, gene associated with retinoic and IFN-induced mortality 12 protein
, gene associated with retinoic and interferon-induced mortality 12 protein
, thioredoxin reductase GRIM-12
, thioredoxin reductase TR1
, redox enzyme thioredoxin reductase
, NADPH-dependent thioredoxin reductase
, selenoprotein oxidoreductase
, TR alpha