Hepatitis A Virus Cellular Receptor 2 蛋白 (HAVCR2)产品概述

Cow (Bovine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

1. The Tim-3/Gal-9 (显示 LGALS9 蛋白) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

1. TIM-3 and IL-37 may be used as potential biomarkers of active rheumatoid arthritis.

2. High TIM3 expression is associated with gastric cancer.

3. miR (显示 MLXIP 蛋白)-498 can effectively suppress TIM-3 expression in the acute myeloid leukemia (显示 BCL11A 蛋白) cell line

4. These results indicate that TIM-3 may be involved in the pathogenesis of immune thrombocytopenia which subsequently can represent an opportunity for new therapeutic plan, moreover. This may have a prognostic value for disease severity.

5. Within many tumors, PD-1 (显示 PDCD1 蛋白)/Tim-3 coexpressing CD8 (显示 CD8A 蛋白)-T cells lose their ability to secrete cytokines and their intratumoral infiltration correlates with a bad prognosis. Tim-3 appeared as a potential biomarker of anti-PD-1 (显示 PDCD1 蛋白) resistance. Combined blockade of PD-1 (显示 PDCD1 蛋白) and Tim-3 axis demonstrated potent clinical efficacy in preclinical models and reinforced the rationale of using an anti-Tim-3 to override tumor resistance.[review]

6. this study shows that TIM-3 expression identifies a distinctive PD-1 (显示 PDCD1 蛋白)(+) follicular helper T cell subset, with reduced interleukin 21 (显示 IL21 蛋白) production and B cell help function in ovarian cancer patients

7. TIM-3 high expression rate was an independent prognostic factor for extranodal NK/T cell lymphoma, nasal type

8. The expression of Tim-3 on CD14 (显示 NDUFA2 蛋白)+ monocytes is involved in systemic inflammatory reaction after intracerebral hemorrhage.

9. TIM-3 gene may play an important role as a genetic risk factor for the progression and prognosis of invasive breast cancer.

10. Tim-3(+) NK cells had decreased capability of IFN-r (显示 IFNAR2 蛋白) secretion, while Tim-3(+) monocytes showed a M2-like phenotype. Importantly, Tim-3 level on both NK cells and monocytes positively correlated with the ratio of Ki-67 (显示 MKI67 蛋白)(+) tumor cells.

Mouse (Murine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

1. Here, the authors demonstrate that Tim-3 inhibits macrophage phagocytosis of Listeria monocytogenes by inhibiting the nuclear erythroid 2-related factor 2 (Nrf2 (显示 NFE2L2 蛋白)) signaling pathway and increases bacterial burden.

2. Studied role of Tim-3 role's in T cell activation using a chronic disease model. Results showed a major function of Tim-3 is to enhance T cell activation during either acute or chronic viral infection, and that Tim-3 is not required for the development of T cell exhaustion.

3. the data suggested that Tim-3 played a crucial role in the macrophage polarization and brain inflammation following intracerebral hemorrhage

4. Tim-3 might contribute to successful pregnancy by restraining Th1 (显示 HAND1 蛋白) bias

5. synergism in cell death by Caspase-1 (显示 CASP1 蛋白)- and RipK3 (显示 RIPK3 蛋白) resulted in restriction of PD-1 (显示 PDCD1 蛋白) and TIM3 expression on primed CD8 (显示 CD8A 蛋白)(+) T cells, which promoted the survival of activated CD8 (显示 CD8A 蛋白)(+) T cells.

6. these findings reveal a critical role for Tim-3-Gal-9 (显示 LGALS9 蛋白) signaling-mediated immunoregulation by pNK (显示 PNKP 蛋白) cells in maternal-fetal immune tolerance and suggest that Tim-3 abundance on pNK (显示 PNKP 蛋白) cells is a potential biomarker for recurrent miscarriage diagnosis.

7. Tim-3 and PD-1 (显示 PDCD1 蛋白) pathways play critical roles in regulating CD8 (显示 CD8A 蛋白)(+) T cell function and maintaining normal pregnancy.

8. CB2R (显示 CNR2 蛋白) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (显示 HIF1A 蛋白)/TIM-3 signalling pathway in microglia

9. Our results show that Tim-3 is a critical negative regulator of NLRP3 (显示 NLRP3 蛋白) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.

10. demonstrated that both IL-10 (显示 IL10 蛋白) and TGF-beta (显示 TGFB1 蛋白) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (显示 SRC 蛋白) and Bruton's tyrosine kinase (显示 BTK 蛋白)