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The Tim-3/Gal-9 (显示 LGALS9 蛋白) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
TIM-3 and IL-37 may be used as potential biomarkers of active rheumatoid arthritis.
High TIM3 expression is associated with gastric cancer.
miR (显示 MLXIP 蛋白)-498 can effectively suppress TIM-3 expression in the acute myeloid leukemia (显示 BCL11A 蛋白) cell line
These results indicate that TIM-3 may be involved in the pathogenesis of immune thrombocytopenia which subsequently can represent an opportunity for new therapeutic plan, moreover. This may have a prognostic value for disease severity.
Within many tumors, PD-1 (显示 PDCD1 蛋白)/Tim-3 coexpressing CD8 (显示 CD8A 蛋白)-T cells lose their ability to secrete cytokines and their intratumoral infiltration correlates with a bad prognosis. Tim-3 appeared as a potential biomarker of anti-PD-1 (显示 PDCD1 蛋白) resistance. Combined blockade of PD-1 (显示 PDCD1 蛋白) and Tim-3 axis demonstrated potent clinical efficacy in preclinical models and reinforced the rationale of using an anti-Tim-3 to override tumor resistance.[review]
this study shows that TIM-3 expression identifies a distinctive PD-1 (显示 PDCD1 蛋白)(+) follicular helper T cell subset, with reduced interleukin 21 (显示 IL21 蛋白) production and B cell help function in ovarian cancer patients
TIM-3 high expression rate was an independent prognostic factor for extranodal NK/T cell lymphoma, nasal type
The expression of Tim-3 on CD14 (显示 NDUFA2 蛋白)+ monocytes is involved in systemic inflammatory reaction after intracerebral hemorrhage.
TIM-3 gene may play an important role as a genetic risk factor for the progression and prognosis of invasive breast cancer.
Tim-3(+) NK cells had decreased capability of IFN-r (显示 IFNAR2 蛋白) secretion, while Tim-3(+) monocytes showed a M2-like phenotype. Importantly, Tim-3 level on both NK cells and monocytes positively correlated with the ratio of Ki-67 (显示 MKI67 蛋白)(+) tumor cells.
Here, the authors demonstrate that Tim-3 inhibits macrophage phagocytosis of Listeria monocytogenes by inhibiting the nuclear erythroid 2-related factor 2 (Nrf2 (显示 NFE2L2 蛋白)) signaling pathway and increases bacterial burden.
Studied role of Tim-3 role's in T cell activation using a chronic disease model. Results showed a major function of Tim-3 is to enhance T cell activation during either acute or chronic viral infection, and that Tim-3 is not required for the development of T cell exhaustion.
the data suggested that Tim-3 played a crucial role in the macrophage polarization and brain inflammation following intracerebral hemorrhage
Tim-3 might contribute to successful pregnancy by restraining Th1 (显示 HAND1 蛋白) bias
synergism in cell death by Caspase-1 (显示 CASP1 蛋白)- and RipK3 (显示 RIPK3 蛋白) resulted in restriction of PD-1 (显示 PDCD1 蛋白) and TIM3 expression on primed CD8 (显示 CD8A 蛋白)(+) T cells, which promoted the survival of activated CD8 (显示 CD8A 蛋白)(+) T cells.
these findings reveal a critical role for Tim-3-Gal-9 (显示 LGALS9 蛋白) signaling-mediated immunoregulation by pNK (显示 PNKP 蛋白) cells in maternal-fetal immune tolerance and suggest that Tim-3 abundance on pNK (显示 PNKP 蛋白) cells is a potential biomarker for recurrent miscarriage diagnosis.
Tim-3 and PD-1 (显示 PDCD1 蛋白) pathways play critical roles in regulating CD8 (显示 CD8A 蛋白)(+) T cell function and maintaining normal pregnancy.
CB2R (显示 CNR2 蛋白) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (显示 HIF1A 蛋白)/TIM-3 signalling pathway in microglia
Our results show that Tim-3 is a critical negative regulator of NLRP3 (显示 NLRP3 蛋白) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
demonstrated that both IL-10 (显示 IL10 蛋白) and TGF-beta (显示 TGFB1 蛋白) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (显示 SRC 蛋白) and Bruton's tyrosine kinase (显示 BTK 蛋白)
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog