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BMP4 (显示 BMP4 蛋白)-dependent expression of Xenopus Grainyhead-like 1 has a critical role in epidermal differentiation
Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3 (显示 GRHL3 蛋白), which may be regulated by miR (显示 MLXIP 蛋白)-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL (显示 GHRL 蛋白) genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 (显示 GRHL3 蛋白) gene or functioning of encoded protein
All of these processes involve epithelial-mesencyhmal transition (EMT (显示 ITK 蛋白)), MET or a sequence of both, suggesting that the GRHL (显示 GHRL 蛋白) factors((GRHL1, GRHL2 (显示 GRHL2 蛋白) and GRHL3 (显示 GRHL3 蛋白)), could potentially affect tumor initiation and progression via EMT (显示 ITK 蛋白)
it was observed that ER stimulated gene expression by interacting with MEIS1 (显示 MEIS1 蛋白) and FOXP3 (显示 FOXP3 蛋白), and ER inhibited gene expression by interacting with THRB (显示 THRB 蛋白) and GRHL1.
Grhl1 deficiency affects inner ear development in zebrafish.
GRHL1, GRHL2 (显示 GRHL2 蛋白), and GRHL3 (显示 GRHL3 蛋白) have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
Downregulation of miR122 by grainyhead-like 2 (显示 GRHL2 蛋白) restricts the hepatocytic differentiation potential of adult liver progenitor cells.
A significant role for HDAC3 (显示 HDAC3 蛋白) in the MYCN (显示 MYCN 蛋白)-mediated repression of GRHL1.
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 (显示 GRHL2 蛋白) in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
LBP-1b (显示 UBP1 蛋白) and LBP-9 (显示 TFCP2L1 蛋白) both stimulate LBP-32/MGR promoter activity.
Includes a comparison to TFCP2L2, the GRHL1 protein.
Significant changes in blood pressure were observed in mice lacking the GRHl1 gene following high and low sodium diet.
No involvement of Grhl1 in blood pressure regulation, but Grhl1 expression influences the regulation of heart rate.
Grainyhead like 1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals and is epidermally expressed
Grhl (显示 GHRL 蛋白) genes are highly expressed in the developing epidermis.
Important regulator of the desmoglein 1 (显示 DSG1 蛋白) genes in the context of hair anchorage and epidermal differentiation.
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development.
, grainyhead-like protein 1 homolog
, grainyhead-like-1 protein
, transcription factor CP2-like 2
, LBP protein 32
, mammalian grainyhead
, transcription factor LBP-32
, grainyhead like 1
, p61 MGR
, p70 MGR
, DNA methyltransferase 3A